{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:46:11Z","timestamp":1791899171268,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bisnicalaterine alkaloids are structurally complex and biologically significant bisindole natural products. Herein, we report the first enantioselective total syntheses of bisnicalaterines B, C, and their\n                    <jats:italic>N<\/jats:italic>\n                    4\u2019 epimers using an eight\u2010step longest linear sequence. Central to this strategy is a site\u2010 and stereoselective bioinspired Friedel\u2013Crafts\u2010type coupling between the eburnamine and geissoschizol fragment, enabling a highly selective formation of the bisindole core. The geissoschizol framework is efficiently assembled using a stereocontrolled Bischler\u2013Napieralski cyclization\/reduction sequence and an organocatalytic enantioselective Michael addition, which establishes the C3 and C15 stereocenters with high fidelity. In addition, the stereochemical relationship between the\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010fused indoloquinolizidine cores is delineated, offering new insight into conformational control within this alkaloid family. This concise synthetic route not only provides the first laboratory access to these unique natural products but also establishes geissoschizol as a versatile platform for the synthesis of other monoterpenoid indole alkaloids (MIAs) and bisindole alkaloids.\n                  <\/jats:p>","DOI":"10.1002\/chem.71328","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:06:06Z","timestamp":1782576366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Divergent Total Syntheses of Bisnicalaterine Alkaloids Enabled by a Stereocontrolled Geissoschizol Synthesis"],"prefix":"10.1002","volume":"32","author":[{"given":"Sittisak","family":"Oekchuae","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chuo\u2010ku Chiba Japan"},{"name":"Program in Chemical Sciences Chulabhorn Graduate Institute  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Matsumiya","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Rakumitsu","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-2583","authenticated-orcid":false,"given":"Hayato","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Chiba University  Chuo\u2010ku Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113786"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NP00011K"},{"key":"e_1_2_7_4_1","first-page":"259","volume-title":"The Alkaloids: Chemistry and Biology","author":"Kitajima M.","year":"2016"},{"key":"e_1_2_7_5_1","first-page":"181","volume-title":"The Alkaloids: Chemistry and Biology","author":"Kam T. 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