{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:02:44Z","timestamp":1784300564534,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chiral alcohols are significant organic compounds that serve as key building blocks for the synthesis of many pharmaceuticals and fine chemicals. The asymmetric reduction of prochiral ketones via\u00a0coupled photocatalytic\u2013biocatalytic systems\u00a0has emerged as one of the most promising and sustainable routes.\u00a0In this study, we report an aminomethyl\u2010polystyrene resin coupled eosin\u2010B (PSR@Eb)\u00a0solar light harvesting photocatalyst which is synthesized via acid\u2010amine coupling approach. Notably,\u00a0\u00a0the as prepared\u00a0PSR@Eb\u00a0photocatalyst exhibit an excellent photocatalytic activity for the NADPH regeneration and\u00a0asymmetric reduction of acetophenones to\u00a0a chiral alcohol (1\u2010phenyl ethanol).\u00a0Additionally, this\u00a0asymmetric reduction proceeds under mild and environmentally benign conditions through\u00a0alcohol dehydrogenase (ADH)\u2010mediated catalysis, eliminating the need for stoichiometric metal\u2010based reductants. This coupled\u00a0photocatalytic\u2010biocatalytic\u00a0photoreactors offers a sustainable route for the synthesis of optically enriched alcohols, which are of significant application to the\u00a0pharmaceutical, flavor and fragrance, and agrochemical industries.<\/jats:p>","DOI":"10.1002\/chem.71348","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:02:57Z","timestamp":1784296977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photocatalytic\/Bio\u2010Catalytic Coupled Photoreactor for Asymmetric Reduction of Acetophenones Under Solar Light"],"prefix":"10.1002","author":[{"family":"Shambhavee","sequence":"first","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-5259","authenticated-orcid":false,"given":"Rajesh K.","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4395-8315","authenticated-orcid":false,"given":"Shaifali","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5895-7860","authenticated-orcid":false,"given":"Kanchan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4723-3377","authenticated-orcid":false,"given":"Rehana","family":"Shahin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Starex University  Gurugram Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupma","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8236-6598","authenticated-orcid":false,"given":"Vinay Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3111-8016","authenticated-orcid":false,"given":"Anurag","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Environmental Science Madan Mohan Malaviya University of Technology  Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-4758","authenticated-orcid":false,"given":"Jin\u2010Ook","family":"Baeg","sequence":"additional","affiliation":[{"name":"Korea Research Institute of Chemical Technology  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1039\/C4GC00885E","article-title":"A solar Light\u2010Driven Eco\u2010Friendly Protocol for Highly Enantioselective Synthesis of Chiral Alcohols via Photocatalytic\/Biocatalytic Cascades","volume":"16","author":"Choudhury S.","year":"2014","journal-title":"Green Chemistry"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11120-013-9824-3","article-title":"Light Harvesting in Photosystem II","volume":"116","author":"Van Amerongen H.","year":"2013","journal-title":"Photosynthesis Research"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1002\/anie.201206019","article-title":"A Photocatalyst\/Enzyme Couple That Uses Solar Energy in the Asymmetric Reduction of Acetophenones","volume":"51","author":"Choudhury S.","year":"2012","journal-title":"Angewandte Chemie International Edition"},{"issue":"12","key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1021\/ar900209b","article-title":"Solar Fuels via Artificial Photosynthesis","volume":"42","author":"Gust D.","year":"2009","journal-title":"Accounts of Chemical Research"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.copbio.2003.09.007","article-title":"Regeneration of cofactors for use in biocatalysis","volume":"14","author":"\u00c3 H. Z.","year":"2003","journal-title":"Current Opinion in Biotechnology"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.molcatb.2006.06.005","article-title":"Visible\u2010Light Photocatalytic Regeneration of NADH Using P\u2010Doped TiO 2 Nanoparticles","volume":"43","author":"Shi Q.","year":"2006","journal-title":"Journal of Molecular Catalysis B: Enzymatic"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s12596-024-01726-z","article-title":"Shining Light on Innovation\u00a0: In \u2011 Situ Crafted Polymeric Frameworks Unveil Spectacular Optical Prowess for Enhanced Photocatalysis","volume":"54","author":"Singhal R.","year":"2025","journal-title":"Journal of Optics"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.1039\/D5SC02770E","article-title":"A Path to Perpetual Chemical Synthesis via Photocatalytic Cofactor Regeneration","volume":"16","author":"Jain V.","year":"2025","journal-title":"Chemical Science"},{"key":"e_1_2_6_10_1","first-page":"4256","article-title":"Recent Progress and Perspectives on Electrochemical Regeneration of Reduced Nicotinamide Adenine Dinucleotide (NADH)","volume":"15","author":"Immanuel S.","year":"2020","journal-title":"Chemistry: An Asian Journal"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2018.00196","article-title":"Citrate as Cost\u2010Efficient NADPH Regenerating Agent","volume":"6","author":"Oeggl R.","year":"2018","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c02548"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00649"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202200888"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.foodchem.2018.12.035","article-title":"Characterization of Enzymes Specifically Producing Chiral Flavor Compounds (R)\u2014and (S) \u20101\u2010Phenylethanol From tea (Camellia Sinensis) Flowers","volume":"280","author":"Zhou Y.","year":"2019","journal-title":"Food Chem"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","unstructured":"P.Michal \u201cEnzyme Synthesis and Continuous Flow Separation of (R) \u20101\u2010Phenylethanol in a Modular Microfluidic System Luk a \u201d360(2025) https:\/\/doi.org\/10.1016\/j.seppur.2024.131041.","DOI":"10.1016\/j.seppur.2024.131041"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1039\/D2RE00203E","article-title":"Polystyrene\u2010Based Eosin\u2010Y as a Photocatalyst for Solar Light\u2010Mediated NADH\/NADPH Regeneration and Organic Transformations","volume":"8","author":"Singh P.","year":"2023","journal-title":"Reaction Chemistry & Engineering"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/cc0498635","article-title":"Preparation of Core\u2014Shell\u2010Type Aminomethyl Polystyrene Resin and Characterization of Its Functional Group Distribution","volume":"7","author":"Shell\u2010type P. C.","year":"2005","journal-title":"Journal of Combinatorial Chemistry"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","unstructured":"F.Bano R. K.Yadav R.Shahin S.Mishra andS.Singh \u201cHighly Efficient Nitrogen\u2010Doped Graphene Coupled Eosin\u2010B Photocatalyst for Fixation and Regeneration of N 2 and NADH Cofactors Under Visible Light \u201d23 no.4(2024):483\u2013497.","DOI":"10.3233\/MGC-240036"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"11455","DOI":"10.1021\/ja3009902","article-title":"A Photocatalyst\u2013Enzyme Coupled Artificial Photosynthesis System for Solar Energy in Production of Formic Acid from CO2","volume":"134","author":"Yadav R. K.","year":"2012","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1039\/c1gc15424a","article-title":"Enzymatic reductions for the chemist","volume":"13","author":"Hollmann F.","year":"2011","journal-title":"Green Chemistry"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3906\/kim-1912-23","article-title":"The Production of Enantiomerically Pure 1\u2010Phenylethanol by Enzymatic Kinetic Resolution Method Using Response Surface Methodology","volume":"44","author":"Bozan A.","year":"2020","journal-title":"Turkish Journal of Chemistry"},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1021\/jo00031a037","article-title":"Lactobacillus Kefir Alcohol Dehydrogenase: A Useful Catalyst for Synthesis","volume":"57","author":"Bradshaw C. W.","year":"1992","journal-title":"Journal of Organic Chemistry"},{"key":"e_1_2_6_24_1","first-page":"781","article-title":"Stereoselective Hydroxylation of Ethylbenzene to (R) \u20101\u2010Phenylethanol Using Mycelia of Aspergillus Niger as Catalyst","volume":"12","author":"Yadav S.","year":"2011","journal-title":"CATCOM"},{"key":"e_1_2_6_25_1","unstructured":"V. A.Online A. C.Evans A. S.Petit S. G.Guillen A. J.Neukirch andN. C.Jones (2021):1635\u20131643 small molecules \u2013 experimental and computational and anisotropy spectroscopy \u2020."},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41929-025-01433-3","article-title":"Enantioselective Energy Transfer Catalysis Compartmentalized by Triplet Photoenzymes","volume":"8","author":"Yang X.","year":"2025","journal-title":"Nature Catalysis"},{"key":"e_1_2_6_27_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tetasy.2008.12.035","article-title":"Tetrahedron\u00a0: Asymmetry Recent Progress in Biocatalysis for Asymmetric Oxidation and Reduction","volume":"20","author":"Matsuda T.","year":"2009","journal-title":"Tetrahedron: Asymmetry"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.25026\/jtpc.v4i4.204","article-title":"Synthesis and Characterization of Methyl Amino Polystyrene as Resin Material of Chromatography","volume":"4","author":"Herman A. A.","year":"2018","journal-title":"Journal Of Tropical Pharmacy And Chemistry"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00436-021-07395-2","article-title":"Preparation, Characterization, and Evaluation of Eosin B \u2013 Loaded Nano\u2010 Liposomes for Growth Inhibition of Plasmodium Falciparum","volume":"121","author":"Najafzadeh M.","year":"2022","journal-title":"Parasitology Research"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00289-025-05815-2","volume-title":"Efficient Removal of Eosin B and Bismarck Brown Dyes Through Microwave Assisted Synthesis of Pectin and Pullulan Based Hydrogel","author":"Nandal K.","year":"2025"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jphotochem.2003.12.012","article-title":"Photodegradation of Dye Pollutants on Silica Gel Supported TiO2 Particles Under Visible Light Irradiation","volume":"163","author":"Chen Y.","year":"2004","journal-title":"Journal of Photochemistry and Photobiology A: Chemistry"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.mspro.2012.06.058","article-title":"Synthesis of Polystyrene Microspheres to be Used as Template in the Preparation of Hollow Spherical Materials: Study of the Operative Variables","volume":"1","author":"Gorsd M. N.","year":"2012","journal-title":"Procedia Materials Science"},{"issue":"9","key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1021\/acsaenm.5c00568","article-title":"Synergistic Tridoped Graphitic Carbon Nitride\u00a0: A Multifunctional Photocatalyst for Suzuki Coupling and NADPH Regeneration","volume":"3","author":"Sharma K.","year":"2025","journal-title":"ACS Applied Engineering Materials"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71348","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:03:02Z","timestamp":1784296982000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":32,"alternative-id":["10.1002\/chem.71348"],"URL":"https:\/\/doi.org\/10.1002\/chem.71348","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"2026-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71348"}}