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The transformation employs Pd(OAc)\n                    <jats:sub>2<\/jats:sub>\n                    (20\u00a0mol %) in combination with the organic photocatalyst eosin Y (WS, 10\u00a0mol %) under irradiation with a 24\u00a0W blue LED, using bench\u2010stable\n                    <jats:italic>N<\/jats:italic>\n                    \u2010halo\u20105,5\u2010dimethylhydantoins (DCDMH, DBDMH, and DIDMH) as sustainable halogen sources. Conducted in 1,2\u2010dichloroethane (DCE) with\n                    <jats:italic>p<\/jats:italic>\n                    \u2010toluenesulfonic acid (1.0 equiv.) as an essential additive, the reaction proceeds under oxidant\u2010free and thermally mild conditions to afford\n                    <jats:italic>ortho<\/jats:italic>\n                    \u2010halogenated products in high isolated yields (75%\u201397%) with excellent regioselectivity. A broad range of substituents on the 3\u2010aryl ring, including electron\u2010donating, electron\u2010withdrawing, and extended aromatic groups, are well tolerated. Mechanistic investigations\u2010including radical trapping experiments (TEMPO, BHT), light on\/off studies, and control reactions\u2010support a cooperative pathway involving Pd(II)\u2010directed C\u2500H activation and photoredox\u2010mediated generation of halogen radicals, followed by radical capture and reductive elimination from high\u2010valent palladium intermediates. This operationally simple dual catalytic approach provides an efficient platform for late\u2010stage diversification of pharmaceutically relevant 2\n                    <jats:italic>H<\/jats:italic>\n                    \u2010benzo[\n                    <jats:italic>b<\/jats:italic>\n                    ][1,4]oxazin\u20102\u2010one scaffolds and advances sustainable strategies in photocatalytic C\u2500H halogenation.\n                  <\/jats:p>","DOI":"10.1002\/chem.71349","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:32:34Z","timestamp":1783099954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light Driven Pd\u2010catalyzed Regioselective C\u2500H Halogenation of Benzo[\n                    <i>b<\/i>\n                    ][1,4]oxazin\u20102\u2010ones Using DXDMH"],"prefix":"10.1002","volume":"32","author":[{"family":"Monika","sequence":"first","affiliation":[{"name":"Bioorganic Laboratory Department of Chemistry University of Delhi  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kumar","sequence":"additional","affiliation":[{"name":"Bioorganic Laboratory Department of Chemistry University of Delhi  Delhi India"},{"name":"Department of Chemistry SRM University Delhi\u2010NCR  Sonepat Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-3996","authenticated-orcid":false,"given":"Brajendra K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Bioorganic Laboratory Department of Chemistry University of Delhi  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4QO01562B"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.11.230"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2021.152879"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397918108063618"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00128a024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2024.155419"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00120"},{"key":"e_1_2_8_9_1","volume-title":"Electrophilic Halogenation: Reaction Pathways Involving Attack by Electrophilic Halogens on Un\u2010 Saturated Compounds; Cambridge Chemistry Texts","author":"Mare P. 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