{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:33:03Z","timestamp":1793194383032,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403198"],"award-info":[{"award-number":["52403198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,10,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intracellular liquid\u2010liquid phase separation underpins the formation of biomolecular condensates that spatially organize and regulate biochemical reactions. Synthetic coacervates have emerged as promising analogues for constructing biomimetic microreactors; however, their practical utility is often limited by poor stability under harsh conditions, such as extreme pH and high ionic strength, which are relevant to both prebiotic environments and chemical processes. Here, we report a bioinspired strategy to construct tripeptide\u2010based coacervates that exhibit exceptional tolerance across a broad range of pH and salt concentrations. By integrating aromatic residues and oligo(ethylene glycol) moieties into minimal peptide sequences, the resulting coacervates establish a dynamic yet robust microenvironment capable of partitioning diverse active species, including enzymes and both hydrophilic and hydrophobic substrates. This confined environment enables concentrating reactants and sustains catalytic activity under various conditions. As a result, these tripeptide coacervates function as versatile microreactors that enhance the efficiency of multiple chemical transformations, including bioorthogonal click reactions, nucleophilic aromatic substitution, and enzyme\u2010mediated hydrolysis. This work demonstrates that short peptides can be rationally engineered to yield environmentally resilient and functionally versatile coacervate systems, providing a minimalistic platform for robust biomimetic catalysis with potential applications in prebiotic chemistry and synthetic biology.<\/jats:p>","DOI":"10.1002\/chem.71406","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:41:32Z","timestamp":1783514492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["pH\u2010Tolerant Tripeptide Coacervates as Biomimetic Catalytic Microreactors"],"prefix":"10.1002","volume":"32","author":[{"given":"Zhanghuan","family":"Li","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu P. R. China"},{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Han","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Pu","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu P. R. China"},{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Song","sequence":"additional","affiliation":[{"name":"Life\u2010Like Materials and Systems Department of Chemistry University of Mainz University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-0999","authenticated-orcid":false,"given":"Zhichao","family":"Pei","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Pharmacy Northwest A&amp;F University  Yangling P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-2407","authenticated-orcid":false,"given":"Shoupeng","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering National Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00307G"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00409"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202913"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201703806"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36060-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172046"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202517620"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010024\u201000635\u2010w"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00615"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00114"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010023\u201000052\u20106"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010022\u201001046\u2010y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4382"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00664"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c15328"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.2c00239"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068980\u20106"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010025\u201001800\u20104"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010025\u201002053\u20105"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202418431"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.293"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS01203H"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010021\u201000788\u2010x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53699-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c17880"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43272-5"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057772\u2010z"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.139604"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c14469"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44278-9"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202420399"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c00224"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05101"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.05.009"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010019\u20100129\u20108"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00592"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00089"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c03793"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c10784"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010021\u201000854\u20104"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00176A"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC00993A"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00883E"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2511"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422601"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.149469"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fochx.2025.103098"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4FO03963G"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.123924"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202519342"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71406","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:42:09Z","timestamp":1793191329000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":51,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2026,10,22]]}},"alternative-id":["10.1002\/chem.71406"],"URL":"https:\/\/doi.org\/10.1002\/chem.71406","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71406"}}