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However, current fluorescence imaging systems for H\n                    <jats:sub>2<\/jats:sub>\n                    S critically lack ratiometric probes that simultaneously feature a single excitation wavelength alongside both working and reference emission bands operating entirely within the second near\u2010infrared (NIR\u2010II) window. To address this gap, we present a NIR\u2010II ratiometric nanohybrid, ErNPs@mSiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Cy\u2010NO\n                    <jats:sub>2<\/jats:sub>\n                    , that integrates Er\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010doped lanthanide downconversion nanoparticles encapsulated by mesoporous silica loading with NIR II cyanine dye (Cy\u2010NO\n                    <jats:sub>2<\/jats:sub>\n                    ). In the presence of H\n                    <jats:sub>2<\/jats:sub>\n                    S, Cy\u2010NO\n                    <jats:sub>2<\/jats:sub>\n                    is converted to Cy\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    , regulating an intramolecular photoinduced electron\u2010transfer (PET) process. Under single 980\u00a0nm excitation, this reaction selectively modulates the \u223c1026\u00a0nm emission (located in NIR II), while the Er\n                    <jats:sup>3+<\/jats:sup>\n                    emission at 1550\u00a0nm (located in NIR II) remains invariant and serves as an internal reference. The resulting fully NIR II ratiometric readout (I\n                    <jats:sub>1026<\/jats:sub>\n                    \/I\n                    <jats:sub>1550<\/jats:sub>\n                    ) enables real\u2010time visualization of H\n                    <jats:sub>2<\/jats:sub>\n                    S in vitro and in vivo. Overall, ErNPs@mSiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010Cy\u2010NO\n                    <jats:sub>2<\/jats:sub>\n                    establishes a robust platform for monitoring of H\n                    <jats:sub>2<\/jats:sub>\n                    S and holds broad potential for advanced biosensing and diagnostic applications.\n                  <\/jats:p>","DOI":"10.1002\/chem.71421","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:19:58Z","timestamp":1784200798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Near\u2010Infrared II Nanohybrid Enables Single\u2010Excitation, Fully Ratiometric Imaging of Hydrogen Sulfide In Vivo"],"prefix":"10.1002","volume":"32","author":[{"given":"Shibi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4964-9330","authenticated-orcid":false,"given":"Lei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pulp &amp; Paper Science and Technology of Shandong Province\/Ministry of Education Qilu University of Technology, Shandong Academy of Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Chemistry Capital Normal University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00028.2021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14091145"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.661"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2023.125043"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00525"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.750926"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106739"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15984"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4659"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-00995-8"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-021-1779-7"},{"key":"e_1_2_8_13_1","first-page":"868","article-title":"Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S\u2010persulfidation","volume":"19","author":"Sun H. 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