{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:09:13Z","timestamp":1785420553507,"version":"3.56.0"},"reference-count":84,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alkene difunctionalization represents one of the most powerful and straightforward tools for the rapid assembly of structurally diverse organic molecules. This review provides a comprehensive overview of recent developments in the difunctionalization of alkenes enabled by photoinduced oxidative radical\u2010polar crossover (ORPC). By merging the advantages of radical reactivity and polar reaction pathways, this strategy enables the efficient construction of diverse 1,2\u2010difunctionalized skeletons under mild and controllable photochemical conditions. We systematically categorize these advances according to the type of radical species that add to the carbon\u2013carbon double bond: carbon\u2010centered radicals (including alkyl, acyl, and allenyl radicals, etc.) and heteroatom\u2010centered radicals (focusing on nitrogen\u2010centered, sulfur\u2010centered radicals, and oxygen\u2010centered radicals). Mechanistic aspects involving radical generation, photoexcitation pathways, and various nucleophiles are discussed to underscore the distinctive role of photoredox catalysis in these transformations. Furthermore, we highlight the substrate scope, functional group tolerance, and synthetic utility of these reactions in complex molecule assembly and drug discovery.<\/jats:p>","DOI":"10.1002\/chem.71480","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:25:06Z","timestamp":1785417906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Difunctionalization of Alkenes via Photoinduced Oxidative Radical\u2010Polar Crossover"],"prefix":"10.1002","author":[{"given":"Yiman","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory for Development and Utilization of Forest Food Resources Nanjing Forestry University, The Interdisciplinary Innovation Institute of Chinese Materia Medica and Forestry Engineering Nanjing University of Chinese Medicine\/Nanjing Forestry University, The First Affiliated Hospital with Nanjing Medical University Nanjing Jiangsu 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