{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:58:59Z","timestamp":1791899939197,"version":"4.3.4"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PZ00P2_209115"],"award-info":[{"award-number":["PZ00P2_209115"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Herein, we report the first successful turnover of \u03b1\u2010SF\n                    <jats:sub>5<\/jats:sub>\n                    substrates in metal\u2010catalyzed cross\u2010coupling chemistry. Previously reported conditions suitable to couple CF\n                    <jats:sub>3<\/jats:sub>\n                    \u2010derivatives under\n                    <jats:italic>Negishi<\/jats:italic>\n                    \u2010type conditions lead to complete decomposition of the corresponding SF\n                    <jats:sub>5<\/jats:sub>\n                    derivatives. We report the first thermally stable \u03b1\u2010SF\n                    <jats:sub>5<\/jats:sub>\n                    organometallic reagent, which allows for a set of catalytic key transformations, delivering the reaction products in good to excellent yields (up to 96%). This organozinc platform allows for extensive downstream functionalization by protonation, allylation and acylation reactions under copper catalysis, as well as palladium\u2010catalyzed\n                    <jats:italic>Negishi\u2010<\/jats:italic>\n                    type cross\u2010coupling conditions. Connecting our experimental results to computational analysis shines first light on the parameters critical for successful turnover of \u03b1\u2010SF\n                    <jats:sub>5<\/jats:sub>\n                    substrates. We challenge our key hypothesis of the critical contribution of the M\u2500C\u2500S angle to reduce orbital overlap, promoting \u03b2\u2010F elimination. While we found a significant contribution of a secondary S\u2500M bond, the central component responsible for suppression of \u03b2\u2010F elimination seems to be the steric bulk of the SF\n                    <jats:sub>5<\/jats:sub>\n                    substituent itself. Additionally, the close proximity of the two potential energy surfaces is proposed to facilitate either reductive elimination, forming alkene \u03c0\u2010complexes, or thermodynamically favored \u03b2\u2010F elimination, highlighting the requirement for careful kinetic control of the reaction.\n                  <\/jats:p>","DOI":"10.1002\/chem.71510","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:47:11Z","timestamp":1786697231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enabling Cross\u2010Coupling Reactivity of \u03b1\u2010Pentafluorosulfanyl Compounds with a Thermally Stable Organozinc \u03b1\u2010SF\n                    <sub>5<\/sub>\n                    Reagent"],"prefix":"10.1002","author":[{"given":"Lujie","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6673-9567","authenticated-orcid":false,"given":"David","family":"Rombach","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/cr500336u","article-title":"Preparation and Utility of Organic Pentafluorosulfanyl\u2010Containing Compounds","volume":"115","author":"Savoie P. 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