{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:44:17Z","timestamp":1785757457092,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ama121040"],"award-info":[{"award-number":["JP25ama121040"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fully substituted acyclic enolates are valuable intermediates for the enantioselective construction of \u03b1\u2010quaternary carbonyl compounds, yet reliable control of enolate geometry\u2014particularly for aldehydes\u2014remains difficult under conventional deprotonation conditions. \u03b2\u2010Oxy vinylbenziodoxoles (VBXs), accessible through two complementary pathways, provide stereodefined acyclic enolate precursors that retain alkene geometry through subsequent cross\u2010coupling and carbonate formation. These VBXs undergo configuration\u2010retentive Sonogashira coupling, enabling modular installation of alkynyl substituents. Subsequent conversion to allyl enol carbonates furnishes ketone\u2010 and aldehyde\u2010type enolate surrogates with defined\n                    <jats:italic>E<\/jats:italic>\n                    \/\n                    <jats:italic>Z<\/jats:italic>\n                    configuration. Under Pd\/Trost\u2010ligand conditions, these carbonates participate in enantioselective decarboxylative allylic alkylation to deliver \u03b1\u2010quaternary ketones and aldehydes in high yields and enantioselectivities. The decisive role of enolate geometry is demonstrated by the opposite sense of asymmetric induction for\n                    <jats:italic>E<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010isomers of the carbonate precursor. The resulting alkynyl\u2010substituted products are readily diversified through manipulation of the allyl, alkynyl, and carbonyl groups.\n                  <\/jats:p>","DOI":"10.1002\/chem.71513","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:46:03Z","timestamp":1785753963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Programmable Access to \u03b1\u2010Quaternary Ketones and Aldehydes via Stereodefined \u03b2\u2010Oxy Vinylbenziodoxoles"],"prefix":"10.1002","author":[{"given":"Shuma","family":"Sasaki","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-8832","authenticated-orcid":false,"given":"Jun","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical 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