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In addition to magnetic resonance imaging contrast, SPIONs can be labeled with radioisotopes incorporated into the crystalline structure or functionalized with chemically bound dyes or chelating agents, enabling complementary imaging modalities such as fluorescence imaging and positron emission tomography. However, chemical functionalization of nanoparticles with targeting ligands can induce alterations not only in their physicochemical properties but also in their interactions with biological systems. These nano\u2010biointeractions are critical determinants of biological performance and must be carefully evaluated. In this study, we investigate the impact of ligand functionalization on SPION\u2010cancer cell interactions to elucidate key parameters relevant to the successful clinical translation of nanomedicine\u2010based targeted imaging agents.<\/jats:p>","DOI":"10.1002\/chem.71517","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:08:16Z","timestamp":1785935296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron Oxide Nanoparticles for Ligand\u2010Mediated Targeted Imaging"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-5017","authenticated-orcid":false,"given":"Claudia Miranda\u2010P\u00e9rez","family":"de Alejo","sequence":"first","affiliation":[{"name":"Centre for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA)  San Sebasti\u00e1n Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES) 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