{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:44:57Z","timestamp":1785757497930,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22371305"],"award-info":[{"award-number":["22371305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22577166"],"award-info":[{"award-number":["22577166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92353301"],"award-info":[{"award-number":["92353301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["87000\u201031670001"],"award-info":[{"award-number":["87000\u201031670001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Copper and zinc homeostasis is tightly regulated in mammalian cells, and their dysregulation is implicated in various pathological conditions including cancer. Herein, we have designed rhenium (I) complexes with Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    chelating properties, exhibiting significant antiproliferative activities against various tumor cell lines. Mechanistic studies have found that mitochondria\u2010targeted complex\n                    <jats:bold>Re2<\/jats:bold>\n                    induces a substantial increase in the intracellular Cu\/Zn levels, especially in the mitochondrial compartment, disrupting the homeostasis of copper and zinc ions in cells and mitochondria, thereby triggering cuproptosis, GSDMD\u2010mediated pyroptosis, and p16\/p21\u2010dependent cellular senescence signaling pathway simultaneously. Moreover, co\u2010incubation with copper\/zinc ions can further enhance the antitumor activity of\n                    <jats:bold>Re2<\/jats:bold>\n                    significantly. In the 4T1 murine breast cancer model,\n                    <jats:bold>Re2<\/jats:bold>\n                    demonstrated potent tumor suppression efficacy with excellent in vivo biocompatibility. This work suggests that intervening in copper and zinc homeostasis is an effective means of regulating multiple programmed cell death, providing new strategies for the rational design of the next\u2010generation metal\u2010based antitumor agents.\n                  <\/jats:p>","DOI":"10.1002\/chem.71521","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T10:54:14Z","timestamp":1785754454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria\u2010Targeted Re (I) Complex Triggers Cuproptosis and Pyroptosis by Regulating Copper\/Zinc Homeostasis in Cancer Cells"],"prefix":"10.1002","author":[{"given":"Jiemin","family":"Zhang","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"Lu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Xu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandi","family":"Cao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong\u2010Wan","family":"Mao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-2942","authenticated-orcid":false,"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, IGCME, School of Chemistry Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.09.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216348"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2024.04.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14247"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806296115"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.12.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c12847"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c04022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB02886K"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c07917"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"0698","DOI":"10.34133\/research.0698","article-title":"Unveiling the Cuproptosis in Colitis and Colitis\u2010Related Carcinogenesis: A Multifaceted Player and Immune Moderator","volume":"8","author":"Liu J.","year":"2025","journal-title":"Research"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s12276-021-00591-1","article-title":"ZIP8 exacerbates Collagen\u2010induced Arthritis by Increasing Pathogenic T Cell Responses, Experimental and Molecular Medicine","volume":"53","author":"Kang J. 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