{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:31:41Z","timestamp":1793719901613,"version":"4.6.1"},"reference-count":20,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303365"],"award-info":[{"award-number":["82303365"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"published-print":{"date-parts":[[2026,11,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemotherapy remains a major strategy for cancer treatment, with cisplatin widely used as a first\u2010line agent for diverse malignancies. Although cisplatin efficiently induces tumor cell death through DNA damage, its therapeutic efficacy is often limited by the development of an immunosuppressive tumor microenvironment that restricts effective immune activation. Here, we report a rationally engineered photosensitizer, CMPE, featuring efficient reactive oxygen species (ROS) generation and precise mitochondrial targeting. Upon spatially controlled light activation, CMPE induces mitochondrial oxidative stress and, in combination with cisplatin, triggers potent immunogenic cell death accompanied by robust release of damage\u2010associated molecular patterns that promote immune cell maturation and activation. In vivo, CMPE in combination with cisplatin enhances CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration while reducing immunosuppressive cell populations, thereby converting immunologically \u201ccold\u201d tumors into an immune\u2010active phenotype and ultimately leading to significant tumor growth inhibition. Moreover, tumor cells pretreated with CMPE, either alone or combined with cisplatin, function as an effective whole\u2010cell vaccine that elicits durable immune memory and suppresses tumor recurrence. These findings demonstrate that a mitochondria\u2010targeted photosensitizer can serve as an effective platform for synergistic chemo\u2010photodynamic immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/chem.71531","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:43:11Z","timestamp":1786624991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Robust Mitochondria\u2010Targeted Photosensitizer Synergizes With Cisplatin Chemotherapy for Enhanced Antitumor Immunity"],"prefix":"10.1002","volume":"32","author":[{"given":"Wudama","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Interventional Therapy Peking University Cancer Hospital (Inner Mongolia Campus) &amp; Affiliated Cancer Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Bai","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Shun Meng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Cancer Hospital (Inner Mongolia Campus) &amp; Affiliated Cancer Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Cancer Hospital (Inner Mongolia Campus) &amp; Affiliated Cancer Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhe","family":"An","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Cancer Hospital (Inner Mongolia Campus) &amp; Affiliated Cancer Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Cancer Hospital (Inner Mongolia Campus) &amp; Affiliated Cancer Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Life Sciences Hebei Agricultural University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine The Second Affiliated Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-2457","authenticated-orcid":false,"given":"Duo","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat\u2010Sen University Sun Yat\u2010Sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences Hebei Agricultural University  Baoding P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy Peking University Cancer Hospital (Inner Mongolia Campus) &amp; Affiliated Cancer Hospital of Inner Mongolia Medical University  Hohhot Inner Mongolia Autonomous Region P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2022.188678"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010024\u201003397\u20105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2447403"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/2056\u20104538.70015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100014\u2010x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201734"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233826"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010022\u201001132\u20102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003221\u20102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26041613"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217079"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.02.037"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011325"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202418894"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c00891"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c02019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c01659"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113720"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71531","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:01:40Z","timestamp":1793718100000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":20,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,11,3]]}},"alternative-id":["10.1002\/chem.71531"],"URL":"https:\/\/doi.org\/10.1002\/chem.71531","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2026-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71531"}}