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Their structures were elucidated by comprehensive spectroscopic analyses, single\u2010crystal x\u2010ray diffraction, and quantum chemical nuclear magnetic resonance (NMR) and electronic circular dichroism (ECD) calculations. Among them, macluphlebones A\u2013C feature three unprecedented carbon skeletons, each possessing a highly oxygenated cyclopenta[\n                    <jats:italic>b<\/jats:italic>\n                    ]chromene core, while macluphlebones C\u2013E represent the first examples of PAPs containing a primary enamine group. Putative biosynthetic pathways involving skeletal rearrangement and degradation processes are proposed to account for the formation of these unique scaffolds. Biologically, some isolates exhibited significant, dose\u2010dependent anti\u2010renal fibrosis effects at noncytotoxic concentrations, underscoring their potential value in antifibrotic drug research.\n                  <\/jats:p>","DOI":"10.1002\/chem.71537","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:23:39Z","timestamp":1785821019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skeleton\u2010Rearranged Prenylated Acetophenone Dimers With Anti\u2010Renal Fibrosis Activity From\n                    <i>Maclurodendron oligophlebium<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-2136","authenticated-orcid":false,"given":"Jing\u2010Jing","family":"Qi","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research, Chinese Academy of Sciences Shanghai Institute of Materia Medica  Shanghai People's Republic of 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