{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:09Z","timestamp":1787721609153,"version":"build-2784847793"},"reference-count":66,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001827","name":"Universiteit van Amsterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chemotherapy stands out as an effective cancer treatment, although typically accompanied by side effects arising from systemic toxicity of anticancer drugs due to the limited specific targeting of tumor cells. In this study, we present a self\u2010assembled Ru\u2010based polysaccharide photocatalyst that selectively targets cancer cells and catalyzes the prodrug\u2010to\u2010drug conversion upon exposure to visible light. The self\u2010assembled photocatalyst forms via supramolecular interactions between \u03b2\u2010cyclodextrins attached to the hyaluronic acid polymer and the adamantane\u2010functionalized tris(bipyridine)ruthenium(II) complex. This polymer supported photocatalysts enables precise targeting of cancer cells as it recognized the CD44 receptor, while the light driven conversion allows for temporal and spatial control over drug production. We demonstrate that both the pro\u2010probe (Rho\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    ) and the prodrug (DOX\u2010L\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    ) can be efficiently converted into the respective active compounds through visible light irradiation, using the supramolecular photocatalyst. The supramolecular photocatalyst targets MCF\u20107 cancer cells over noncancerous NIH3T3 cells, converting Rho\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    upon irradiation only when the catalyst is present in the cell. In line with this, irradiation of MCF\u20107 cells that were exposed to DOX\u2010L\u2010N\n                    <jats:sub>3<\/jats:sub>\n                    induces increased cell death. This strategy is a way forward to efficient, controllable, and targeted activation of prodrugs within cancer cells.\n                  <\/jats:p>","DOI":"10.1002\/chem.71603","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:38:57Z","timestamp":1787719137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Cancer Cells With Self\u2010Assembled Ru\u2010Polysaccharide Photocatalyst for Visible\u2010Light\u2010Induced Activation of Prodrugs"],"prefix":"10.1002","author":[{"given":"Jianghua","family":"Liu","sequence":"first","affiliation":[{"name":"Homogeneous, Supramolecular and Bio\u2010Inspired Catalysis (HomKat), Van \u2018t Hoff Institute For Molecular Sciences (HIMS) University of Amsterdam (UVA)  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinghao","family":"Wu","sequence":"additional","affiliation":[{"name":"Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry Leiden University  Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-3048","authenticated-orcid":false,"given":"Alexander","family":"Kros","sequence":"additional","affiliation":[{"name":"Supramolecular and Biomaterials Chemistry, Leiden Institute of Chemistry Leiden University  Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-508X","authenticated-orcid":false,"given":"Joost N. 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