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This limited membrane permeability can reduce drug efficacy and allow bacteria to deploy various defense mechanisms. In this study, we show that small synthetic anionophores can significantly enhance the antibacterial activity of anionic antibiotics by accelerating their transmembrane transport. In liposomes, these anionophores increase the transmembrane transport rate of carboxylate drugs by over two orders of magnitude, even when present in catalytic amounts. In bacteria, the same artificial carriers amplify the activity of clinically used anionic antibiotics, markedly enhancing their antimicrobial activity against both Gram\u2010positive and Gram\u2010negative strains. Notably, the extent of this activity enhancement directly correlates with the carrier\u2010induced increase in drug permeability. 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