{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:22:48Z","timestamp":1788531768766,"version":"build-2803163510"},"reference-count":284,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The synthesis and characterization of organo\u2010selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired antioxidants; the investigation and exploitation of selenium\u2500metal motifs in biological and medicinal chemistry represent a recent development and constitute the focus of this review. Selenoproteins are targets of metal ions like mercury and cadmium, whose toxicity is associated with the formation of stable selenium\u2500metal bonds impairing protein function. On the other hand, selenium\u2500metal bonding provides a strategy for tuning both chalcogen and metal reactivity, potentially enhancing the pharmacological performance of metallodrugs. Coordination to transition metals can modify redox potentials, bond polarization, and reactivity, thereby enabling multifunctional compounds combining metal\u2010based pharmacophores with the redox activity of selenium. These systems may modulate reactive oxygen species, inhibit enzymes, and enhance selective cytotoxicity toward cancer cells. The formation of selenium\u2500metal bonds in biological environment can also alter the function of metalloproteins, accounting for the toxicity of organoselenides. By combining experimental structural and reactivity properties with mechanistic insights from computational chemistry, we highlight the unifying concepts that govern selenium\u2500metal bonding and to illustrate how these concepts can guide the rational design of new classes of selenium\u2010based functional molecules.<\/jats:p>","DOI":"10.1002\/chem.71645","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:46:49Z","timestamp":1788529609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium\u2500Metal Motif in Toxicology and Medicinal Chemistry"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1249-5630","authenticated-orcid":false,"given":"Matteo","family":"Filippi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche Universit\u00e0 di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5594-991X","authenticated-orcid":false,"given":"Alessandro","family":"Rubbi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche Universit\u00e0 di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9133-6102","authenticated-orcid":false,"given":"Pablo A.","family":"Nogara","sequence":"additional","affiliation":[{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia Sul\u2010Rio\u2010Grandense (IFSul)  Bag\u00e9 Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-5530","authenticated-orcid":false,"given":"Giovanni","family":"Ribaudo","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Molecolare e Traslazionale Universit\u00e0 di Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-576X","authenticated-orcid":false,"given":"Vito","family":"Lippolis","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche Universit\u00e0 degli Studi di Cagliari  Monserrato Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-0595","authenticated-orcid":false,"given":"Jo\u00e3o B. T.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Biologia Molecolar Universidade Federal de Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-5111","authenticated-orcid":false,"given":"Laura","family":"Orian","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche Universit\u00e0 di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202403003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NJ05694A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10101560"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272822666180803123137"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2026.104083"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.05.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.011"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.01.014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432\u20101327.2000.01701.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010061516\u2010045037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753\u20103322(03)00035\u20100"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666220801165849"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.05.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17568919.2024.2435254"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","DOI":"10.1039\/9781788011907","volume-title":"Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments","author":"Jain V. K.","year":"2017"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23042360"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0406559"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/B978-0-323-90219-9.00005-4","volume-title":"Redox Chemistry and Biology of Thiols","author":"Nogara P. A.","year":"2022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.03.006"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60272a"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010nutr\u2010071714\u2010034250"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","DOI":"10.1039\/9781839167386","volume-title":"Chalcogen Chemistry: Fundamentals and Applications","author":"Lippolis V.","year":"2023"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30030437"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2013"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050799"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210109"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2024.12.028"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.16.7708"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.08.043"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010476"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c02382"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.213885"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114834"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300\u2010483X(83)90040\u20109"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201014\u2010629"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00884"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2019.01.006"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9026"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20101033.2004.04251.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/15230860152542998"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00374"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201402256"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.1c00073"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.5c00409"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsorginorgau.1c00047"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.26371"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29010120"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.035"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.2174\/2212796811307010002"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00031"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2052520616003954"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202401431"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.59761\/RCR5143"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NJ02364D"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213537"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox5040042"},{"key":"e_1_2_8_60_1","volume-title":"Free Radicals in Biology and Medicine","author":"Halliwell B.","year":"2010"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12090874"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009\u20102541(00)00246\u20101"},{"key":"e_1_2_8_63_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-319-60189-2_4","volume-title":"Neurotoxicity of Metals","author":"Oliveira C. S.","year":"2017"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34361"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c06269"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coal.2019.103251"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/min9070455"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054353"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365518109092041"},{"key":"e_1_2_8_70_1","first-page":"286","article-title":"Monitoring of Selenium in Oral Cavity Argyria\u2014A Clinical and Microscopic Study","volume":"32","author":"Vencl\u00edkov\u00e1 Z.","year":"2011","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.6036"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162\u20100134(98)10048\u2010X"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167\u20104838(98)00221\u20100"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031305"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121566"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7861"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.30921"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.03.241"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.05.023"},{"key":"e_1_2_8_80_1","unstructured":"Servier Medical Art can be found underhttps:\/\/smart.servier.com\/(accessed 5 May 2026)."},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2024.102495"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.613406"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr800557s"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.08.022"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100773.1984.tb01930.x"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/115.4.454"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.47.31"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010026\u201002142\u2010z"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c19556"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/57.1.22"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010026\u201004637\u2010x"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202311_34326"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010026\u201008466\u2010x"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17172838"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2025.114737"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013\u20109351(05)80248\u20108"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/0048\u20109697(90)90055\u2010Y"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29010136"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/152165400410263"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CP04386C"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2008.10.029"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216549600201851"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010014\u20101218\u20102"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145338"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201220n"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20109861(79)90277\u20107"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp219"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2018.04.013"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184448"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.12.002"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.9b03072"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00326"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijhydene.2013.04.132"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03489"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2335"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5304.1305"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20102126(02)00826\u20102"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.06.031955"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.105990"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11686\u2010025\u201001128\u20106"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA05987A"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.161"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7719159"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MT00201G"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980431o"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.213905"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214836"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2JA00090C"},{"key":"e_1_2_8_129_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1201\/9781003300496-11","volume-title":"Toxicology of Essential and Xenobiotic Metals","author":"Nogara P. A.","year":"2024"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.32.20096"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2004.04.020"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500135391"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(90)90387\u2010Z"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.020701"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010009\u20100466\u2010z"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00164\u201009"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.70283"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.21926\/aeer.2104033"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2016.10.009"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2020.09.020"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic200199b"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic702037k"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03619"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c01454"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.05.009"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics6030047"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010007\u20100209\u20102"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2019.01.007"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1897\/08\u2010375.1"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00342295"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00234a030"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic900827m"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5QI01958C"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710133200"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfad014"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044\u20100305(03)00141\u20107"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2701"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.03.018"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c02568"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c01708"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx100080s"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic1021406"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126\u2010013\u20109508\u20101"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c04948"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2007.07.015"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17113782"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12060388"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.27.59"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002449910047"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22170"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03808"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00080C"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.03.026"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013\u20109351(76)90012\u20108"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9507911"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045\u20106535(98)00591\u20108"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144314"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2022.120980"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsenvironau.1c00022"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1039\/b608078b"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b00840"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC02232B"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1437S"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1114"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1448789"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101916"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583510000089"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2017.71"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300801R"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13070825"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3489"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.1910"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.2174\/2212796811307010006"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20102952(02)01414\u20104"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2008.12.007"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20105793(02)03890\u20105"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic401429z"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.01.013"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2018.04.009"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic200267x"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202400252"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002375\u2010x"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00685"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/222385a0"},{"key":"e_1_2_8_205_1","doi-asserted-by":"crossref","DOI":"10.1002\/9783906390420","volume-title":"Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug","author":"Lippert B.","year":"1999"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2021.03.006"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT03919C"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02135970"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1969.10665508"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.09.027"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010022\u201024783\u2010y"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.119461"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201006\u20100581"},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1524099"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.166234"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118361"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC04082G"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.01.013"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26144230"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20102952(84)90083\u20102"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19240570703"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400063"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.19080\/CTOIJ.2019.14.555883"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2019.03.013"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200461471"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13080192"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c00455"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201548z"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol036283s"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012741107"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050420"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210791209009"},{"key":"e_1_2_8_233_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900134a"},{"key":"e_1_2_8_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2016.06.021"},{"key":"e_1_2_8_235_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00338"},{"key":"e_1_2_8_236_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph6111361"},{"key":"e_1_2_8_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205900"},{"key":"e_1_2_8_238_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00332C"},{"key":"e_1_2_8_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20107258(87)90009\u2010X"},{"key":"e_1_2_8_240_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/201367"},{"key":"e_1_2_8_241_1","doi-asserted-by":"publisher","DOI":"10.1039\/b924677k"},{"key":"e_1_2_8_242_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201904382"},{"key":"e_1_2_8_243_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202012620"},{"key":"e_1_2_8_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.01.007"},{"key":"e_1_2_8_245_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502925"},{"key":"e_1_2_8_246_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00180"},{"key":"e_1_2_8_247_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800076105"},{"key":"e_1_2_8_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2024.106939"},{"key":"e_1_2_8_249_1","first-page":"209","article-title":"Selenium in the Treatment of Heavy Metal Poisoning and Chemical Carcinogenesis","volume":"6","author":"Whanger P. D.","year":"1992","journal-title":"Journal of Trace Elements and Electrolytes in Health and Disease"},{"key":"e_1_2_8_250_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081078"},{"key":"e_1_2_8_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.10.054"},{"key":"e_1_2_8_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.09.009"},{"key":"e_1_2_8_253_1","unstructured":"R. F.StockelandP. E.Dumas \u201cUse of Selenium\u2010Containing Compounds for Negating the Toxic Effects of Platinum Compounds Used in Chemotherapy and a Novel Selenium\u2010Containing Platinum Compound and Use Thereof as an Anti\u2010Cancer Medicine \u201d (1986):4617189."},{"key":"e_1_2_8_254_1","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfad020"},{"key":"e_1_2_8_255_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010024\u201002072\u2010y"},{"key":"e_1_2_8_256_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c08885"},{"key":"e_1_2_8_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2006.03.008"},{"key":"e_1_2_8_258_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic902335z"},{"key":"e_1_2_8_259_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13091078"},{"key":"e_1_2_8_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2017.08.003"},{"key":"e_1_2_8_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2017.07.034"},{"key":"e_1_2_8_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2018.01.032"},{"key":"e_1_2_8_263_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201898"},{"key":"e_1_2_8_264_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC04490A"},{"key":"e_1_2_8_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102621"},{"key":"e_1_2_8_266_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS00924C"},{"key":"e_1_2_8_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2010.10.026"},{"key":"e_1_2_8_268_1","first-page":"1679","article-title":"Uptake and Efflux of Rhenium in Cells Exposed to Rhenium Diseleno\u2010Ether and Tissue Distribution of Rhenium and Selenium After Rhenium Diseleno\u2010Ether Treatment in Mice","volume":"34","author":"Collery P.","year":"2014","journal-title":"Anticancer Research"},{"key":"e_1_2_8_269_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010015\u20100265\u2010z"},{"key":"e_1_2_8_270_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11194"},{"key":"e_1_2_8_271_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010019\u201000727\u20101"},{"key":"e_1_2_8_272_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.17394"},{"key":"e_1_2_8_273_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.16889"},{"key":"e_1_2_8_274_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.7b00362"},{"key":"e_1_2_8_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.12.001"},{"key":"e_1_2_8_276_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7487"},{"key":"e_1_2_8_277_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867329666211222115035"},{"key":"e_1_2_8_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.07.033"},{"key":"e_1_2_8_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2010.02.009"},{"key":"e_1_2_8_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.05.039"},{"key":"e_1_2_8_281_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152012803529682"},{"key":"e_1_2_8_282_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00706\u2010014\u20101197\u20106"},{"key":"e_1_2_8_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2004.02.004"},{"key":"e_1_2_8_284_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201011\u20101218"},{"key":"e_1_2_8_285_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01399"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:46:57Z","timestamp":1788529617000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":284,"alternative-id":["10.1002\/chem.71645"],"URL":"https:\/\/doi.org\/10.1002\/chem.71645","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]},"assertion":[{"value":"2026-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71645"}}