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Herein, we have reported a new Y(III)\u2010based chemically stable framework,\n                    <jats:bold>IITKGP\u201065,<\/jats:bold>\n                    with abundant active catalytic sites, which exhibited excellent stability in open air, water, and even in acidic medium. The activated framework,\n                    <jats:bold>IITKGP\u201065a<\/jats:bold>\n                    , has been utilized as a Lewis acid\u2010driven heterogeneous catalyst for the synthesis of bioactive chromeno[2,3\u2010\n                    <jats:italic>d<\/jats:italic>\n                    ]pyrimidin\u20108\u2010amine derivatives. Notably, synthesis of these compounds has not yet been reported in the literature using any coordination polymer\u00a0(CP) or metal\u2013organic framework\u00a0(MOF)\u2010based catalyst. Interestingly, a good to excellent yield was achieved even with a low catalyst loading of our developed catalyst for a wide range of substrate scopes, along with excellent recyclability without any loss of structural integrity. Most importantly, to demonstrate practical applicability, we synthesized four chromeno[2,3\u2010\n                    <jats:italic>d<\/jats:italic>\n                    ]pyrimidin\u20108\u2010amine derivatives exhibiting\n                    <jats:italic>antibacterial activity<\/jats:italic>\n                    using a green ethanol medium. The facile accessibility, robust structural framework, outstanding catalytic performance, and excellent recyclability collectively underscore the potential of the developed framework,\n                    <jats:bold>IITKGP\u201065<\/jats:bold>\n                    , as an efficient catalyst. Furthermore, these attributes extend its applicability to the environmentally friendly synthesis of complex bioactive molecules.\n                  <\/jats:p>","DOI":"10.1002\/chem.71648","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:05:18Z","timestamp":1788523518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Highly Robust Y\u2010Based Framework for Sustainable Catalysis and Synthesis of Bioactive Chromeno[2,3\u2010\n                    <i>d<\/i>\n                    ]Pyrimidin\u20108\u2010Amine Derivatives"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1760-7327","authenticated-orcid":false,"given":"Bikram","family":"Pramanik","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Kharagpur  Kharagpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4649-6713","authenticated-orcid":false,"given":"Rupam","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Kharagpur  Kharagpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4751-8235","authenticated-orcid":false,"given":"Sayan","family":"Palit","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Kharagpur  Kharagpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-8705","authenticated-orcid":false,"given":"Madhab C.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Kharagpur  Kharagpur West Bengal 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