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Notably, blapenoids A\u2013I feature a densely oxygenated 7,8\u2010\n                    <jats:italic>seco<\/jats:italic>\n                    \u2010norditerpenoid backbone of the cleistanthane family, branching into the first reported 7,16,17,19,20\u2010pentanor scaffold (blapenoids A\u2212D), and an unprecedented 16,17,19,20\u2010tetranor skeleton (blapenoids E\u2013I), for which a plausible biosynthetic pathway was proposed. Intriguingly, chiral\u2010phase HPLC resolved blapenoids E\u2010G into enantiopure forms, whereas the structurally analogous blapenoids H and I existed as scalemic mixtures (er 35:1,\n                    <jats:italic>R<\/jats:italic>\n                    \/\n                    <jats:italic>S<\/jats:italic>\n                    ). This stereochemical divergence was corroborated by methylation of (+)\u2010 and (\u2212)\u2010blapenoid G, followed by LC\u2010MS analysis. Biological assays revealed that some compounds noncytotoxically inhibited transforming growth factor (TGF\u2010\n                    <jats:italic>\u03b2<\/jats:italic>\n                    )\u2010induced fibrogenesis in human lung fibroblasts. Notably, blapenoid K emerged as the most potent (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 3.82 \u00b5M), dose\u2010dependently suppressing\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2011smooth muscle actin (\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010SMA), fibronectin, and collagen I transcripts, alongside corresponding protein\u2010level inhibition of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010SMA and fibronectin, supporting aromatic norditerpenoids as promising lead compounds for further anti\u2010pulmonary fibrosis research.\n                  <\/jats:p>","DOI":"10.1002\/chem.71683","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:17:22Z","timestamp":1789046242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aromatic Norditerpenoids From\n                    <i>Blachia pentzii<\/i>\n                    With Anti\u2010Pulmonary Fibrosis Activity"],"prefix":"10.1002","author":[{"given":"Zhi\u2010Xiang","family":"Xie","sequence":"first","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of China"},{"name":"School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi\u2010Xi","family":"Tang","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Kang","family":"Cui","sequence":"additional","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9835-922X","authenticated-orcid":false,"given":"Yi","family":"Zang","sequence":"additional","affiliation":[{"name":"Lingang Laboratory  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-4870","authenticated-orcid":false,"given":"Jian\u2010Min","family":"Yue","sequence":"additional","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of China"},{"name":"School of Pharmaceutical Sciences, Cheeloo College of Medicine Shandong University  Jinan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-5320","authenticated-orcid":false,"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ethnomedicine and Biofunctional Molecule Research Center, State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences  Shanghai People's Republic of 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