{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:02:44Z","timestamp":1789650164308,"version":"4.0.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mechanochemistry has emerged a greener and more efficient alternative to solution\u2010based methods for hydrazone synthesis. However, prior studies have predominantly focused on final yields, reaction times, and biological activities, while giving limited attention to reaction kinetics and mixing quality effects, which are essential for process optimization. To address this gap, the present work elucidates the mechanochemical kinetics of hydrazones synthesis from isoniazid and isophthalaldehyde via competitive\u2010consecutive pathways. Although such systems are widely employed in solution to characterize micromixing, no kinetic studies have yet been reported on competitive\u2010consecutive reactions under mechanochemical conditions. In the present study, reactions were conducted in a vibratory ball mill (Pulverisette P0), and the effects of operating parameters on kinetics, yield, selectivity, and mixing quality were systematically assessed. These results were further compared to liquid\u2010phase (EtOH\/H\n                    <jats:sub>2<\/jats:sub>\n                    O) and solid\u2010phase syntheses in the presence of a catalytic amount of water. Dry mechanochemical synthesis proceeded with zero\u2010order kinetics, governed by the balance between energy input and mixing, reflecting an intermediate kinetic\u2010mixing regime. Optimized dry grinding enabled faster conversion, further enhanced by catalytic water addition, while reducing environmental impact; however, liquid\u2010phase selectivity remained superior due to more effective mixing.\n                  <\/jats:p>","DOI":"10.1002\/chem.71700","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:13:17Z","timestamp":1789647197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanochemical Hydrazone Synthesis From Isoniazid and Isophthalaldehyde: Kinetics and Process Optimization of a Competitive\u2010Consecutive Reaction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-7449","authenticated-orcid":false,"given":"Nissrine Al","family":"Assaad","sequence":"first","affiliation":[{"name":"Centre RAPSODEE (Recherche D'albi En G\u00e9nie Des Proc\u00e9d\u00e9s des SOlides Divis\u00e9s De L'energie Et De l'Environnement), IMT Mines Albi, UMR CNRS 5302 Universit\u00e9 De Toulouse Campus Jarlard, All\u00e9e des Sciences  Albi France"},{"name":"Chimie ParisTech UMR CNRS 8060, Institute of Chemistry for Life and Health Sciences PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-1837","authenticated-orcid":false,"given":"Alain","family":"Chamayou","sequence":"additional","affiliation":[{"name":"Centre RAPSODEE (Recherche D'albi En G\u00e9nie Des Proc\u00e9d\u00e9s des SOlides Divis\u00e9s De L'energie Et De l'Environnement), IMT Mines Albi, UMR CNRS 5302 Universit\u00e9 De Toulouse Campus Jarlard, All\u00e9e des Sciences  Albi France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pedr\u00f3n","sequence":"additional","affiliation":[{"name":"Chimie ParisTech UMR CNRS 8060, Institute of Chemistry for Life and Health Sciences PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-4522","authenticated-orcid":false,"given":"Ilaria","family":"Ciofini","sequence":"additional","affiliation":[{"name":"Chimie ParisTech UMR CNRS 8060, Institute of Chemistry for Life and Health Sciences PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-2769","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Labat","sequence":"additional","affiliation":[{"name":"Chimie ParisTech UMR CNRS 8060, Institute of Chemistry for Life and Health Sciences PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-0976","authenticated-orcid":false,"given":"Rachel","family":"Calvet","sequence":"additional","affiliation":[{"name":"Centre RAPSODEE (Recherche D'albi En G\u00e9nie Des Proc\u00e9d\u00e9s des SOlides Divis\u00e9s De L'energie Et De l'Environnement), IMT Mines Albi, UMR CNRS 5302 Universit\u00e9 De Toulouse Campus Jarlard, All\u00e9e des Sciences  Albi France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.58.1324"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010019\u201009974\u2010z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/761030"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.688043"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.03.031"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.09.058"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/12081910"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.05.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010013\u20100632\u20102"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.04.077"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.01.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010011\u20109705\u20102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573406411309010053"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010023\u201003039\u20105"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.48048\/tis.2021.39"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb\u20102019\u20100040"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.07.011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16040484"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.08.003"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.002"},{"key":"e_1_2_8_22_1","unstructured":"P. F. M.Oliveira \u201cInvestigation of Mechanochemical Synthesis of Condensed 1 4\u2010Diazines and Pharmaceutically Attractive Hydrazones \u201d (2015) Universit\u00e9 de Toulouse."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CP00170F"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.141905"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.02.026"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA06845D"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.131546"},{"key":"e_1_2_8_28_1","volume-title":"The IUPAC Compendium of Chemical Terminology","year":"2014"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198506980.001.0001"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.07.056"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8GC01345D"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091457"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA10489G"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.05.034"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp062746a"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853\u2010018\u20102090\u20101"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP01658F"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CP05647B"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CP01361K"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1505"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00062"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202117270"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.13.216"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.0c08314"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0527424"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.1992.469"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.17824"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cherd.2021.07.012"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2020.116397"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2509(94)80078-2"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ceat.200800213"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/op020074q"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20102509(81)80008\u20105"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed065p857"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC00538E"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00997h"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.200900128"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71700","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:13:20Z","timestamp":1789647200000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":56,"alternative-id":["10.1002\/chem.71700"],"URL":"https:\/\/doi.org\/10.1002\/chem.71700","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,17]]},"assertion":[{"value":"2026-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71700"}}