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Nanoparticles had a size of 249.5 \u00b1 12.9\u00a0nm, a polydispersity index of 0.18, a zeta potential of +2.61\u00a0mV, and an encapsulation efficiency of 19%\u00a0w\/w, reflecting a homogeneous distribution, enhanced stability, and high encapsulation efficiency. Fourier\u2010transform infrared (FTIR), x\u2010ray diffraction (XRD), differential scanning calorimetric (DSC), and Nuclear magnetic resonance (NMR) confirmed successful drug encapsulation and its amorphous state. The formulation illustrated enhanced pH\u2010sensitive CBZT release at acidic tumor\u2010like conditions. In vitro HCT116 cell experiments showed that CBZT\u2010PLGA\u2010NPs exhibited higher cytotoxicity than the free drug at 2\u00a0\u00b5g\/mL, profoundly reduced cell migration, and enhanced apoptosis. Flow cytometry demonstrated mitochondrial membrane potential impairment and apoptosis initiation. Molecular docking and dynamics represent strong hydrophobic interactions with the BCL\u20102 receptor. The HET\u2010CAM assay demonstrated remarkable anti\u2010inflammatory effects, with 72.38% \u00b1 1.89% vessel inhibition. This nanoparticle strategy overcomes pharmacokinetic pitfalls of CBZT, which holds promise for targeted colorectal cancer therapeutics, and perhaps beyond.<\/jats:p>","DOI":"10.1002\/chem.71732","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:17:15Z","timestamp":1790338635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Colorectal Cancer Therapy Using Cabozantinib\u2010Loaded PLGA Nanoparticles: Formulation, Cytotoxicity, and Molecular Docking Analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0068-2557","authenticated-orcid":false,"given":"Aryan","family":"Thakkar","sequence":"first","affiliation":[{"name":"School of Pharmacy &amp; Technology Management SVKM'S NMIMS Deemed\u2010to\u2010be University  Shirpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-9582","authenticated-orcid":false,"given":"Sankha","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"School of Pharmacy &amp; 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