{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:59:59Z","timestamp":1790341199685,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007065","name":"Universit\u00e0 degli Studi di Salerno","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Magnetic resonance imaging (MRI) is a powerful diagnostic modality that relies on Gd\n                    <jats:sup>+3<\/jats:sup>\n                    \u2010based contrast agents (GBCAs) to enhance image quality and provide detailed anatomical and functional information. The continued demand for safer and more effective contrast agents has stimulated the development of efficient synthetic routes to macrocyclic gadolinium chelators. In this work, we describe a straightforward synthetic approach to chiral C2\u2010substituted 1,4,7,10\u2010tetraazacyclododecane (cyclen) derivatives\n                    <jats:bold>1\u20133<\/jats:bold>\n                    , obtained through BH\n                    <jats:sub>3<\/jats:sub>\n                    \u2010mediated reduction of cyclic peptoid precursors. These compounds were subsequently converted into the corresponding DOTA\u2010type ligands,\n                    <jats:italic>S<\/jats:italic>\n                    \u2010\n                    <jats:bold>Me\u2010DOTA<\/jats:bold>\n                    ,\n                    <jats:italic>S<\/jats:italic>\n                    \u2010\n                    <jats:bold>Bn\u2010DOTA<\/jats:bold>\n                    , and\n                    <jats:italic>S<\/jats:italic>\n                    \u2010\n                    <jats:bold>iBu\u2010DOTA<\/jats:bold>\n                    , and their Gd\n                    <jats:sup>+3<\/jats:sup>\n                    complexes were evaluated as MRI contrast agents through relaxivity measurements in water and human plasma. In addition, structural characterization of [Eu\u2010\n                    <jats:italic>S<\/jats:italic>\n                    \u2010\n                    <jats:bold>Bn\u2010DOTA<\/jats:bold>\n                    ]\n                    <jats:sup>\u2212<\/jats:sup>\n                    by\n                    <jats:sup>1<\/jats:sup>\n                    H NMR spectroscopy revealed the predominance of the square antiprismatic (SAP) \u039b(\u03b4\u03b4\u03b4\u03b4)\/corner coordination isomer in solution. This work demonstrates the utility of cyclic peptoids as versatile precursors to chiral C\u2010substituted DOTA ligands and provides an alternative route for the development of novel MRI contrast agents.\n                  <\/jats:p>","DOI":"10.1002\/chem.71734","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:02:31Z","timestamp":1790337751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Solid\u2010Phase Approach to Chiral C2\u2010Substituted Cyclen and DOTA\u2010Like Lanthanoid Ligands"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-424X","authenticated-orcid":false,"given":"Rosaria","family":"Schettini","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d University of Salerno  Fisciano SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8679-4879","authenticated-orcid":false,"given":"Roberta","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Bracco Research Centre, Bracco Imaging SpA  Colleretto Giacosa TO Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-7477","authenticated-orcid":false,"given":"Alberto","family":"Fringuello Mingo","sequence":"additional","affiliation":[{"name":"Bracco Research Centre, Bracco Imaging SpA  Colleretto Giacosa TO Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Buonsanti","sequence":"additional","affiliation":[{"name":"Bracco Research Centre, Bracco Imaging SpA  Colleretto Giacosa TO Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-6077","authenticated-orcid":false,"given":"Giovanni","family":"Pierri","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d University of Salerno  Fisciano SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6849-798X","authenticated-orcid":false,"given":"Consiglia","family":"Tedesco","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d University of Salerno  Fisciano SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-7125","authenticated-orcid":false,"given":"Chiara","family":"Costabile","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d University of Salerno  Fisciano SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5020-8502","authenticated-orcid":false,"given":"Giorgio Della","family":"Sala","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d University of Salerno  Fisciano SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-0102","authenticated-orcid":false,"given":"Irene","family":"Izzo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. Zambelli\u201d University of Salerno  Fisciano SA Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-9463","authenticated-orcid":false,"given":"Francesco","family":"De Riccardis","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biology \u201cA. 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