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While chemical ligation addresses this, conventional methods often face difficulties such as side reactions due to the high electrophilicity of\n                    <jats:italic>S<\/jats:italic>\n                    \u2010 or\n                    <jats:italic>O<\/jats:italic>\n                    \u2010acyl donors. Here we developed an\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(2\u2010formylphenyl)\u2010hydroxamate (HDX) ester as an\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acyl donor for chemical ligation involving a direct\n                    <jats:italic>N<\/jats:italic>\n                    \u2010to\u2010\n                    <jats:italic>N<\/jats:italic>\n                    acyl shift, eliminating the need for\n                    <jats:italic>S<\/jats:italic>\n                    \u2010 or\n                    <jats:italic>O<\/jats:italic>\n                    \u2010acyl compounds. 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