{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T09:44:16Z","timestamp":1791971056998,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22571260"],"award-info":[{"award-number":["22571260"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry A European J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Functionalized benzofulvenes and dihydronaphthalenes are privileged scaffolds with profound utility in medicinal chemistry and materials science. However, their modular synthesis is often bottlenecked by a reliance on complex, pre\u2010functionalized precursors and a persistent challenge to control exocyclic\n                    <jats:italic>E\/Z<\/jats:italic>\n                    stereochemistry. Herein, we report a step\u2010economical cascade methodology that successfully bridges reductive radical\u2010involved carbonyl addition with Lewis acid\u2010catalyzed cyclization. By orchestrating a one\u2010pot, chromium\u2010mediated tandem Nozaki\u2013Hiyama\u2013Kishi (NHK) coupling with Lewis acid\u2010catalyzed cyclization, this protocol enables the rapid assembly of complex benzofulvenes and dihydronaphthalene directly from commercially abundant propargyl bromides and aromatic aldehydes or ketones. For benzofulvene synthesis, this cascade generates kinetically sensitive allenol intermediates strictly in situ\u2014circumventing their isolation\u2014and exerts rigorous thermodynamic control to deliver the exocyclic olefin with unprecedented &gt;20:1\n                    <jats:italic>E\/Z<\/jats:italic>\n                    selectivity.\n                  <\/jats:p>","DOI":"10.1002\/chem.71802","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:45:34Z","timestamp":1791967534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stereocontrolled Assembly of Benzofulvenes and Dihydronaphthalenes via a Tandem Chromium Catalyzed NHK\/Cyclization Cascade"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-3491","authenticated-orcid":false,"given":"Xianrong","family":"Zeng","sequence":"first","affiliation":[{"name":"Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science and Research Center For Industries of the Future Westlake University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hainuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science and Research Center For Industries of the Future Westlake University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-2879","authenticated-orcid":false,"given":"Zhaobin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science and Research Center For Industries of the Future Westlake University  Hangzhou Zhejiang China"},{"name":"Institute of Natural Sciences, Westlake Institute for Advanced Study  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm700969c"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201528b"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b00944"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b02219"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010017\u20103667\u20109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma0629236"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202100177"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00516"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NJ05432D"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja405972h"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja037836x"},{"key":"e_1_2_8_13_1","first-page":"8694","article-title":"Effects of Donor Position on Dibenzofulvene\u2010Based Organic Dyes for Photovoltaics","volume":"28","author":"Corrente G. A.","year":"2017","journal-title":"Journal of Materials Science: Materials in Electronics"},{"key":"e_1_2_8_14_1","article-title":"Branched Dibenzofulvene\u2010Based Organic Dyes for Dye\u2010sensitized Solar Cells Under One Sun and Dim Light","volume":"30","author":"Chen Y.\u2010C.","year":"2019","journal-title":"Journal of Materials Science: Materials in Electronics"},{"key":"e_1_2_8_15_1","first-page":"4474","article-title":"Selective [3 + 2] C\u2013H\/C\u2013H Alkyne Annulation via Dual (Distal) C(\n                     \u03b2,\u03b4\n                  )\u2013H Bond Activation Relay: A Novel Therapeutic Quinazolone\u2010Tethered Benzofulvenes for Oral Cancer","volume":"4","author":"Satpute D. P.","year":"2024","journal-title":"Journal of the American Chemical Society Au"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b01564"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201901351"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo001417q"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja026630d"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200351195"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol049122c"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja803413f"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07448"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c03133"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201310530"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c02942"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc201910029"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101218575"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja110650m"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201101364"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b00595"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b03858"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.7690506"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC10057A"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201407358"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200902006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201901530"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/b926763h"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c03720"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c06046"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1021\/ol0600281","article-title":"Novel Synthesis of Bridged Phenylthienylethenes and Dithienylethenes via Pd\u2010Catalyzed Double\u2010Cyclization Reactions of Diarylhexadienynes","volume":"8","author":"Tobe Y.","year":"2006","journal-title":"Organic Letters"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/B607684J"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b02788"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020024j"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201101460"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar900153r"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar4002069"},{"key":"e_1_2_8_48_1","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1002\/anie.200903675","article-title":"Silver and Br\u00f8nsted Acid Catalyzed Nazarov\u2010Type Cyclizations To Generate Benzofulvenes","volume":"48","author":"Gandon V.","year":"2009","journal-title":"Angewandte Chemie International Edition"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00284"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500504w"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2005.05.019"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5c00489"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202117114"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032614\u20104"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c00177"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507474"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12043"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c08493"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.025.202506897"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9703360"},{"key":"e_1_2_8_61_1","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1055\/s-0036-1589457","article-title":"Recent Advances in the Asymmetric Nozaki\u2013Hiyama\u2013Kishi Reaction","volume":"48","author":"Tian Q.","year":"2016","journal-title":"Synthesis"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00144"},{"key":"e_1_2_8_63_1","first-page":"1684","article-title":"Recent Progress in Chromium\u2010Mediated Carbonyl Addition Reactions","volume":"54","author":"Kanai M.","year":"2021","journal-title":"Synthesis"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gresc.2025.07.008"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.025.202506433"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202500242"}],"container-title":["Chemistry \u2013 A European Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/chem.71802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chem.71802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:45:36Z","timestamp":1791967536000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/chem.71802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":65,"alternative-id":["10.1002\/chem.71802"],"URL":"https:\/\/doi.org\/10.1002\/chem.71802","archive":["Portico"],"relation":{},"ISSN":["0947-6539","1521-3765"],"issn-type":[{"value":"0947-6539","type":"print"},{"value":"1521-3765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71802"}}