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A racemic precursor was prepared in high yield from easily available starting products and subjected to HPLC resolution on a noncommercial chiral stationary phase. More than 600 mg of each enantiomer was isolated in optically pure form by using a 150 \u00d7 20 mm ID column containing mixed 10\u2010undecenoate\/3,5\u2010dimethylphenylcarbamate of cellulose covalently bonded to allylsilica gel and a mixture of <jats:italic>n<\/jats:italic>\u2010hexane\/2\u2010propanol\/acetone as the mobile phase. Chirality 14:39\u201346, 2002. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.10036","type":"journal-article","created":{"date-parts":[[2002,9,10]],"date-time":"2002-09-10T15:25:40Z","timestamp":1031671540000},"page":"39-46","source":"Crossref","is-referenced-by-count":21,"title":["First synthesis of the two enantiomers of \u03b1\u2010methyldiphenylalanine [(\u03b1Me)Dip] by HPLC resolution"],"prefix":"10.1002","volume":"14","author":[{"given":"Soledad","family":"Royo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laureano","family":"Oliveros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cativiela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,12,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-440X(92)90110-S"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.61.070192.002131"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-7743(08)60941-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/recl.19941130102"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0282(1997)43:3<219::AID-BIP3>3.0.CO;2-Y"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-440X(92)90117-P"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)00942-9"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma00060a028"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360331011"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)90220-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0282(1996)40:5<523::AID-BIP10>3.0.CO;2-I"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/psc.310010602"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00050a019"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00015a003"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00037a009"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00096a010"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9807439"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja993568k"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00841-8"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1387(199906)5:6<251::AID-PSC190>3.0.CO;2-K"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3011.2001.00840.x"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1039\/a909856i"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)85549-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079508009292"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)01123-4"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)01004-2"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1997)9:2<145::AID-CHIR12>3.0.CO;2-N"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02688470"},{"key":"e_1_2_1_30_2","first-page":"204","article-title":"The Knoevenagel condensation","volume":"15","author":"Jones G","year":"1967","journal-title":"Org React"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO;2-5"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1998-1675"},{"key":"e_1_2_1_33_2","volume-title":"Chromatographic enantioseparation: methods and applications","author":"Allenmark SG","year":"1991"},{"key":"e_1_2_1_34_2","first-page":"115","volume-title":"A practical approach to chiral separations by liquid chromatography","author":"Dingenen J","year":"1994"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/bk-1991-0471.ch005"},{"key":"e_1_2_1_36_2","first-page":"271","volume-title":"Chiral separations. 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