{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:58:43Z","timestamp":1770983923834,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,5,15]],"date-time":"2003-05-15T00:00:00Z","timestamp":1052956800000},"content-version":"vor","delay-in-days":134,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present two methods for the enantioselective analysis of thioridazine (THD) and thioridazine 2\u2010sulfone (THD 2\u2010SO<jats:sub>2<\/jats:sub>) in human plasma based on liquid\u2013liquid extraction with diethyl ether and chiral resolution of the enantiomers on Chiralpak AD and Chiralcel OD\u2010H columns, respectively. After validation, the methods were used to study the degradation and racemization of both drug and metabolite. Our results showed that both enantiomers of THD and THD 2\u2010SO<jats:sub>2<\/jats:sub> were stable at varying temperatures, pH, and ionic strengths; however, solubility problems for THD and THD 2\u2010SO<jats:sub>2<\/jats:sub> enantiomers were observed, mainly at pH 8.5. The influence of light on the stability of the THD and THD 2\u2010SO<jats:sub>2<\/jats:sub> enantiomers was also studied. Degradation of the THD enantiomers was observed under UV light (254 and 366 nm) while THD 2\u2010SO<jats:sub>2<\/jats:sub> enantiomers were stable at these wavelengths and also when exposed to visible light. Chirality 15:479\u2013485, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.10240","type":"journal-article","created":{"date-parts":[[2003,5,26]],"date-time":"2003-05-26T10:03:08Z","timestamp":1053943388000},"page":"479-485","source":"Crossref","is-referenced-by-count":10,"title":["Racemization and degradation of thioridazine and thioridazine 2\u2010sulfone in human plasma and aqueous solutions"],"prefix":"10.1002","volume":"15","author":[{"given":"Cristiane","family":"Masetto de Gaitani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Souto","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierina Sueli","family":"Bonato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,15]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00096-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)80010-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(84)90215-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00007691-198204000-00005","article-title":"Active metabolites of neuroleptic drugs: possible contribution to therapeutic and toxic effects","volume":"4","author":"Dahl SG","year":"1982","journal-title":"Ther Drug Monit"},{"key":"e_1_2_1_6_2","first-page":"463","article-title":"Side effects of thioridazine and their relationship with the serum concentrations of the drug and its main metabolites","volume":"28","author":"Axelsson R","year":"1980","journal-title":"Curr Ther Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/00498259509061859","article-title":"Metabolism of thioridazine by microsomal monoxygenases: relative roles of P450 and flavin\u2010containing monoxygenase","volume":"25","author":"Blake BL","year":"1995","journal-title":"Xenobiotica"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0731-7085(93)80157-V"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199107000-00013"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/17.6.374"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0379-0738(94)90227-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600810324"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(90)90069-E"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.10240","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.10240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:36:19Z","timestamp":1700267779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.10240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/chir.10240"],"URL":"https:\/\/doi.org\/10.1002\/chir.10240","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}