{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:54:29Z","timestamp":1791136469654,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T00:00:00Z","timestamp":1093564800000},"content-version":"vor","delay-in-days":239,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Access to a key 3\u2010aryl\u2010\u03b4\u2010lactone intermediate in enantiopure form using preparative chiral chromatography allowed expedited preparation of an important drug discovery target. A preclinical drug discovery strategy that combines rapid route discovery with effective use of preparative chiral chromatography can result in significant savings of both time and labor. <jats:italic>Chirality 16:609\u2013613, 2004.<\/jats:italic> \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20081","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T15:26:23Z","timestamp":1093620383000},"page":"609-613","source":"Crossref","is-referenced-by-count":24,"title":["Effective use of preparative chiral HPLC in a preclinical drug synthesis"],"prefix":"10.1002","volume":"16","author":[{"given":"Todd D.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline H.","family":"Smitrovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Huffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Mathre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,8,27]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"793","article-title":"Asymmetric processes in the large\u2010scale preparation of chiral drug candidates","author":"O'Brien MK","year":"2000","journal-title":"Curr Opin Drug Disc"},{"key":"e_1_2_1_3_2","first-page":"633","volume-title":"Chemical analysis 142: impact of stereochemistry on drug development and use","author":"Francotte E","year":"1997"},{"key":"e_1_2_1_4_2","first-page":"131","article-title":"Chiral chromatography: given the new techniques in development the use of chiral chromatography in large scale separation of racemic compounds will eventually become commonplace","author":"Cox G","year":"2001","journal-title":"Innov Pharm Tech"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(94)80033-2"},{"key":"e_1_2_1_6_2","first-page":"9","article-title":"Analytical and semi\u2010preparative separation of enantiomers using the Whelko chiral stationary phase: naproxen and abscisic acid as case studies","author":"Welch CJ","year":"1993","journal-title":"Chem New Zealand"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(01)00556-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00173a045"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol0259847"},{"key":"e_1_2_1_10_2","unstructured":"The absolute stereochemistry of the lactone was determined by single\u2010crystal X\u2010ray analysis of a diastereomeric precursor from an alternative route (see Ref. 8)."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00849-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00102a071"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.20081","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.20081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T19:31:39Z","timestamp":1697225499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.20081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/chir.20081"],"URL":"https:\/\/doi.org\/10.1002\/chir.20081","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}