{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:41:29Z","timestamp":1788475289865,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T00:00:00Z","timestamp":1095724800000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The HPLC enantiomer separation of a novel series of C<jats:sub>5<\/jats:sub>\u2010chiral 1\u2010acetyl\u20103\u2010(4\u2010hydroxy\u2010 and 2,4\u2010dihydroxyphenyl)\u20105\u2010phenyl\u20104,5\u2010dihydro\u2010(1<jats:italic>H<\/jats:italic>)\u2010pyrazole derivatives, with inhibitory activity against monoamine oxidases (MAO) type A and B, was accomplished using polysaccharide\u2010based chiral stationary phases (CSPs: Chiralpak AD, Chiralcel OD, and Chiralcel OJ). Pure alcohols, such as ethanol and 2\u2010propanol, and typical normal\u2010phase binary mixtures, such as <jats:italic>n<\/jats:italic>\u2010hexane and alcohol modifier, were used as mobile phases. Single enantiomers of several analytes examinated were isolated on a semipreparative scale, and their chiroptical properties were measured. The assignment of the absolute configuration was established for one compound by single\u2010crystal X\u2010ray diffraction method and for the other three by CD spectroscopy. The inhibitory activity against MAO of racemic samples and single enantiomers were evaluated in vitro. <jats:italic>Chirality 16:625\u2013636, 2004.<\/jats:italic> \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20085","type":"journal-article","created":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T13:00:30Z","timestamp":1095771630000},"page":"625-636","source":"Crossref","is-referenced-by-count":31,"title":["Enantiomers of C<sub>5<\/sub>\u2010chiral 1\u2010acetyl\u20103,5\u2010diphenyl\u20104,5\u2010dihydro\u2010(1<i>H<\/i>)\u2010pyrazole derivatives: Analytical and semipreparative HPLC separation, chiroptical properties, absolute configuration, and inhibitory activity against monoamine 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