{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:32:21Z","timestamp":1791196341767,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T00:00:00Z","timestamp":1113955200000},"content-version":"vor","delay-in-days":109,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enantiomeric separations of four 2\u2010substituted propionic acid drugs have been studied using packed\u2010column supercritical fluid chromatography (SFC) with amylose tris(3,5\u2010dimethylphenylcarbamate) coated on silica as support (Chiralpak AD). Under standard conditions (i.e., flow rate, 1.5 ml\/min; column temperature, 30\u00b0C; back\u2010pressure, 150 bar), the order of elution could be reversed when the polar alcohol modifier methanol in carbon dioxide was replaced by 2\u2010propanol for ibuprofen, ketoprofen, and naproxen. For flurbiprofen, with the highest selectivity factor, no reversal was observed, although selectivity was reduced significantly with higher alcohols. Naproxen and flurbiprofen were also investigated with 2\u2010butanol and 2\u2010pentanol. The former showed reversal of elution order but not the latter. For higher alcohol modifiers, including 2\u2010propanol, the peak symmetry was poor but could be improved by addition of citric acid in the alcohol modifier. These results stress the importance to investigate enantiomer elution order during the development of enantioselective methods and when chromatographic conditions are optimized. Preliminary experiments with column temperatures over the range of \u221215 to 45\u00b0C revealed that, in a few cases, reversal took place with a change in temperature only. <jats:italic>Chirality 17:257\u2013265, 2005.<\/jats:italic> \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20160","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T18:16:35Z","timestamp":1114020995000},"page":"257-265","source":"Crossref","is-referenced-by-count":53,"title":["Reversal of elution order for profen acid enantiomers in packed\u2010column SFC on Chiralpak AD"],"prefix":"10.1002","volume":"17","author":[{"given":"Olle","family":"Gyllenhaal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Stefansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd915"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac00291a017"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00952-3"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-005-3074-y"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac040088p"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01483918808069046"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530060310"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/32.10.439"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00585-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-001-1198-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01330-9"},{"key":"e_1_2_1_13_2","article-title":"Resolution 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