{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:10:32Z","timestamp":1781356232317,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T00:00:00Z","timestamp":1142208000000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The application of a chiral ligand\u2010exchange column (CLEC) for the direct high\u2010performance liquid chromatographic enantioseparation of unusual secondary amino acids using D\u2010penicillamine\u2010Cu(II) complex as chiral selector is reported. The amino acids investigated were pyrrolidine\u20102\u2010carboxylic acid, piperidine\u20102\u2010carboxylic acid, piperazine\u20102\u2010carboxylic acid, morpholine\u20103\u2010carboxylic acid, and thiomorpholine\u20103\u2010carboxylic acid analogs. Chromatographic results are given as the retention, separation, and resolution factors. The chromatographic conditions were varied to achieve optimal separation. The elution sequence of the enantiomers was determined and in most cases the <jats:italic>S<\/jats:italic> isomer eluted before R. Chirality 18:539\u2013543, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20257","type":"journal-article","created":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T20:17:45Z","timestamp":1142281065000},"page":"539-543","source":"Crossref","is-referenced-by-count":17,"title":["High\u2010performance liquid chromatographic enantioseparation of unusual secondary amino acids on a D\u2010penicillamine\u2010based chiral ligand exchange column"],"prefix":"10.1002","volume":"18","author":[{"given":"Istv\u00e1n","family":"Ilisz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Tourw\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antal","family":"P\u00e9ter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,3,13]]},"reference":[{"key":"e_1_2_1_2_2","series-title":"Peptidomimetics protocols","first-page":"321","volume-title":"Methods in molecular medicine","author":"Tourw\u00e9 D","year":"1998"},{"key":"e_1_2_1_3_2","first-page":"1288","article-title":"Ligand chromatography on asymmetric complex\u2010forming sorbents as a new method for resolution of racemates","volume":"192","author":"Rogozhin SV","year":"1970","journal-title":"Dokl Akad Nauk"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)95566-3"},{"key":"e_1_2_1_5_2","volume-title":"Ligand Exchange Chromatography","author":"Davankov VA","year":"1988"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00337a015"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01483918608076651"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079308019570"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079308019646"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00350-V"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(98)00783-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00808-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00909-8"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)00035-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305610"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01475-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00915a026"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bscb.19820910807"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00908563"},{"key":"e_1_2_1_20_2","first-page":"2252","article-title":"Pristinamycin. Synthesis of the linear heptapeptide and oligopeptides corresponding to the IA constituent of pristinamycin","volume":"8","author":"Joll\u00e8s G","year":"1965","journal-title":"Bull Soc Chim Fr"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)00944-2"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/bscb.19830921109"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(81)80170-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo01031a022"},{"key":"e_1_2_1_25_2","unstructured":"R.Callens Ph.D. thesis University of Ghent Belgium 1979."},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00354a034"},{"key":"e_1_2_1_27_2","first-page":"209","article-title":"30 years of chiral ligand exchange","volume":"3","author":"Davankov VA","year":"2000","journal-title":"Enantiomer"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0009999"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00587-8"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.20257","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.20257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:48:00Z","timestamp":1694522880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.20257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/chir.20257"],"URL":"https:\/\/doi.org\/10.1002\/chir.20257","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}