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Selected isomeric human mineralocorticoid receptor (hMR) antagonist pharmaceutical candidates and synthetic intermediates were separated using the Chiralcel\u00ae OJ\u2010H HPLC column with novel polar cosolvent eluent systems. The capacity factors, resolution, and selectivity of the chiral separations were assessed while varying the alcohol\/acetonitrile composition and alcohol identity. The mixed polar eluents provide separations that are nearly always superior to both the traditional hexane\u2010rich and single\u2010alcohol \u201cpolar organic\u201d eluents for the compounds tested in this article. Chirality, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20269","type":"journal-article","created":{"date-parts":[[2006,4,24]],"date-time":"2006-04-24T12:20:39Z","timestamp":1145881239000},"page":"437-445","source":"Crossref","is-referenced-by-count":7,"title":["Enantiomeric separation of mineralocorticoid receptor (hMR) antagonists using the Chiralcel\u00ae OJ\u2010H HPLC column with novel polar cosolvent eluent systems"],"prefix":"10.1002","volume":"18","author":[{"given":"V. 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