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Rate constants<jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub>and<jats:italic>k<\/jats:italic><jats:sub>\u22121<\/jats:sub>and Gibbs activation energies are directly obtained from the chromatographic parameters (retention times<jats:italic>t<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-1.gif\" xlink:title=\"urn:x-wiley:08990042:media:CHIR20276:tex2gif-stack-1\"\/>and<jats:italic>t<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-stack-2.gif\" xlink:title=\"urn:x-wiley:08990042:media:CHIR20276:tex2gif-stack-2\"\/>of the interconverting enantiomers, the peak widths at half height<jats:italic>w<jats:sub>A<\/jats:sub><\/jats:italic>and<jats:italic>w<jats:sub>B<\/jats:sub>,<\/jats:italic>and the relative plateau height<jats:italic>h<jats:sub>p<\/jats:sub><\/jats:italic>), and the initial amounts<jats:italic>A<\/jats:italic><jats:sub>0<\/jats:sub>and<jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub>of the enantiomers without any iterative and time consuming computational step. Therefore, this equation is no longer limited to racemic analytes. The analytical solution presented here was validated by comparison with a dataset of 125,000 simulated elution profiles of enantiomerizations. Furthermore, it was found that the recovery rate from a defined dataset is on average 40% higher using the unified equation compared to evaluation methods based on iterative computer simulation. The new equation was applied to determine the enantiomerization rate constant of 1\u2010<jats:italic>n<\/jats:italic>\u2010butyl\u20102\u2010<jats:italic>tert<\/jats:italic>\u2010butyldiaziridine by enantioselective gas chromatography. The activation parameters (\u0394<jats:italic>H<\/jats:italic><jats:sup>\u2021<\/jats:sup>= 112.6 \u00b1 2.5 kJ\/mol and \u0394<jats:italic>S<\/jats:italic><jats:sup>\u2021<\/jats:sup>= \u221227 \u00b1 2 J\/(K mol) were obtained from temperature\u2010dependent measurements between 100\u00b0C and 140\u00b0C in 10K steps. Chirality 18:489\u2013497, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20276","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T22:17:04Z","timestamp":1146089824000},"page":"489-497","source":"Crossref","is-referenced-by-count":80,"title":["Fast and precise access to enantiomerization rate constants in dynamic chromatography"],"prefix":"10.1002","volume":"18","author":[{"given":"O.","family":"Trapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,26]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"311","article-title":"Nitrogen inversion: experiment and theory","volume":"15","author":"Lehn JM","year":"1970","journal-title":"Topics in Current 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