{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:31:12Z","timestamp":1760887872343},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T00:00:00Z","timestamp":1146009600000},"content-version":"vor","delay-in-days":115,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>(<jats:italic>S<\/jats:italic>)\u2010Ornidazole is a subject of research as an antifertility agent in male animals at present. However, there seems to be no relative report on chiral separation for <jats:italic>rac<\/jats:italic>\u2010Ornidazole, which has been used as an effective medicine for more than 30 years. In this article, the chiral separation of <jats:italic>rac<\/jats:italic>\u2010Ornidazole on a Chiralcel OB\u2010H column based on normal\u2010phase high\u2010performance liquid chromatography (NP\u2010HPLC) is investigated and the methodology for detection of impurity of (<jats:italic>R<\/jats:italic>)\u2010Ornidazole in (<jats:italic>S<\/jats:italic>)\u2010Ornidazole injection and raw material is established. The novel mobile phase is utilized by mixing <jats:italic>n<\/jats:italic>\u2010hexane, methanol and isopropyl alcohol (95:4:1, v\/v\/v) instead of the typical mobile phase of <jats:italic>n<\/jats:italic>\u2010hexane and isopropyl alcohol, although the methanol, which offers a good resolution factor for the enantiomeric separation in this system, is not recommended on the Chiralcel OB\u2010H column according to the instruction supplied by Daicel Chemical Ind., LTD (Japan). Chirality, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20292","type":"journal-article","created":{"date-parts":[[2006,4,26]],"date-time":"2006-04-26T22:18:16Z","timestamp":1146089896000},"page":"587-591","source":"Crossref","is-referenced-by-count":10,"title":["Chiral separation of <i>rac<\/i>\u2010Ornidazole and detection of the impurity of (<i>R<\/i>)\u2010Ornidazole in (<i>S<\/i>)\u2010Ornidazole injection and raw material"],"prefix":"10.1002","volume":"18","author":[{"given":"Jianquan","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junren","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,26]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"44","article-title":"Ornidazole: a new antiprotozoal compound for treatment of Trichomonas vaginalis infection","volume":"53","author":"Skold M","year":"1977","journal-title":"Br J Vener Dis"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00013542-200101000-00001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1000551"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498257909042323"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01990326"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1984.tb00762.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1071\/BI9820595","article-title":"Inhibition of fructolysis in boar spermatozoa by the male antifertility agent (S)\u2010alpha\u2010chlorohydrin","volume":"35","author":"Stevenson D","year":"1982","journal-title":"Aust J boil Sci"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/224083a0"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/004982597240299"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20000601)21:10<1940::AID-ELPS1940>3.0.CO;2-#"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00532-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1997)9:8<722::AID-CHIR2>3.0.CO;2-7"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.20292","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.20292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T23:58:33Z","timestamp":1695945513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.20292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/chir.20292"],"URL":"https:\/\/doi.org\/10.1002\/chir.20292","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}