{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:59:57Z","timestamp":1770983997214,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T00:00:00Z","timestamp":1147996800000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The direct HPLC enantioseparation of Mianserin and a series of aptazepine derivatives is accomplished on polysaccharide\u2010based chiral stationary phases (CSPs). The resolutions are performed on the coated\u2010type Chiralcel OD and Chiralpak AD CSPs and on the first commercially available immobilized\u2010type Chiralpak IA CSP, in normal\u2010phase and polar\u2010organic modes. The complete separation of enantiomers of all racemates investigated was successfully achieved under at least one of CSP\/eluent combinations employed. Pure alcohols such ethanol or 2\u2010propanol, with a fixed percentage of DEA added, serve as valuable alternatives to the more common <jats:italic>n<\/jats:italic>\u2010hexane\u2010based normal\u2010phase eluents in resolution of Mianserin on the AD CSP. In order to study the chiroptical properties of aptazepine derivatives, chromatographic resolutions are carried out at semipreparative scale using Chiralpak AD and Chiralpak IA as CSPs. Nonconventional dichloromethane\u2010based eluents have permitted to expand the chiral resolving ability of the immobilized Chiralpak IA CSP and to perform mg\u2010scale enantioseparations with an analytical\u2010size column. Assignment of the absolute configuration of the separated enantiomers is empirically established by comparing their chiroptical data with those of structurally related Mianserin. Chirality, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20298","type":"journal-article","created":{"date-parts":[[2006,5,19]],"date-time":"2006-05-19T19:59:02Z","timestamp":1148068742000},"page":"621-632","source":"Crossref","is-referenced-by-count":31,"title":["Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and immobilized polysaccharide\u2010based chiral stationary phases"],"prefix":"10.1002","volume":"18","author":[{"given":"Roberto","family":"Cirilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Orlando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosella","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Turchetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romano","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"De Martino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"La Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,5,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540280071036"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006997731966"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570260343"},{"key":"e_1_2_1_5_2","first-page":"7","article-title":"Research on psycotropic agents. 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