{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T04:51:51Z","timestamp":1695617511320},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"vor","delay-in-days":206,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conditions for separation of enantiomers of a mandelic acid derivative, methyl 2\u2010phenyl\u20102\u2010(tetrahydropyranyloxy) acetate (the analyte) were studied. Because of the presence of two chiral carbons, the analyte consists of four stereoisomers stable at ambient temperature. Chiral HPLC of the analyte resulted in four peaks, using an (<jats:italic>S<\/jats:italic>,<jats:italic>S<\/jats:italic>)\u2010Whelk\u2010O1 column with the mobile phase consisting of hexane and the t\u2010butyl methyl ether (TBME). It was found that TBME dramatically changed the retention of the isomers, though it produced the best enantioseparation on (<jats:italic>S<\/jats:italic>,<jats:italic>S<\/jats:italic>)\u2010Whelk\u2010O1. The amount of TBME in the mobile phase influenced the degree of retention shift; 5% (v\/v) TBME gave a bigger shift than 8% (v\/v) and 10% (v\/v). 2\u2010Propanol did not produce the same results. The chiral separation was also tried on cellulose tris (3, 5\u2010dimethyl phenylcarbamate) (CDMPC), but only three peaks were seen, indicating some but not full enantiomer resolution. Chirality, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20304","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T15:17:24Z","timestamp":1153927044000},"page":"757-761","source":"Crossref","is-referenced-by-count":2,"title":["Effect of the mobile phase on the retention behavior of optical isomers of the mandelic acid derivative methyl 2\u2010phenyl\u20102\u2010(tetrahydropyranyloxy) acetate by chiral HPLC"],"prefix":"10.1002","volume":"18","author":[{"given":"Baochun","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beijia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)00258-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01002-0"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(99)00500-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)89534-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr00092a006"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1081\/AL-200060973"},{"key":"e_1_2_1_8_2","first-page":"1717","article-title":"Enantioseparation 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