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Good separation was achieved at 20\u00b0C using cellulose tris\u2010(3,5\u2010dimethylphenylcarbamate) as chiral stationary phase, a mixture of <jats:italic>n<\/jats:italic>\u2010hexane and 2\u2010propanol (97:3) as mobile phase at a flow rate of 1.0 ml\/min. The assay method was linear over a range of concentrations (0.25\u201325 \u03bcg\/ml) in plasma and the mean recovery was greater than 90% for both enantiomers. The limits of quantification and detection for both enantiomers in plasma were 0.25 and 0.1 \u03bcg\/ml, respectively. Intra\u2010 and interday relative standard deviations (RSDs) did not exceed 10% for three\u2010tested concentrations. The method was successfully applied to pharmacokinetic studies of BX enantiomers in rabbits. The result suggested that the pharmacokinetics of BX enantiomers was stereoselective in rabbits. 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