{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:15:13Z","timestamp":1788581713746,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2007,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Many terpenes are used therapeutically, and as flavor and fragrance materials. (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010Carvone, the main constituent of spearmint oil, and (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010carvone, found as major component of caraway and dill seed oils, have several applications and are used in cosmetic, food, and pharmaceutical preparations. In this study, the effect of enantiomers of carvone on the central nervous system (CNS) was evaluated in mice. The LD\n                    <jats:sub>50<\/jats:sub>\n                    value was 484.2 mg\/kg (358.9\u2013653.2) for (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010carvone, and 426.6 (389.0\u2013478.6) mg\/kg for (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010carvone. Both enantiomers caused depressant effects, such as decrease in the response to the touch and ambulation, increase in sedation, palpebral ptosis, and antinociceptive effects. (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010 and (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010carvone caused a significant decrease in ambulation. (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010Carvone appeared to be more effective than its corresponding enantiomer at 0.5 and 2.0 h after administration. However, (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010carvone was slightly more potent at 1 h. In potentiating pentobarbital sleeping time, (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010carvone was more effective than (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010carvone at 100 mg\/kg, but was less potent at 200 mg\/kg compared to the (+)\u2010enantiomer, indicating a sedative action. (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010Carvone at the dose of 200 mg\/kg increased significantly the latency of convulsions induced by PTZ and PIC, but (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010carvone was not effective against these convulsions. These results suggest that (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010carvone and (\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010(\u2212)\u2010carvone have depressant effect in the CNS. (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(+)\u2010Carvone appears to have anticonvulsant\u2010like activity. Chirality, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/chir.20379","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T10:10:24Z","timestamp":1171361424000},"page":"264-268","source":"Crossref","is-referenced-by-count":84,"title":["Influence of the chirality of (\n                    <i>R<\/i>\n                    )\u2010(\u2212)\u2010 and (\n                    <i>S<\/i>\n                    )\u2010(+)\u2010carvone in the central nervous system: A comparative study"],"prefix":"10.1002","volume":"19","author":[{"given":"Dami\u00e3o Pergentino","family":"De Sousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin Ferreira","family":"De Farias n\u00f3brega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo N\u00f3brega","family":"De 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