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The compounds were separated without any derivatization and separation factor range between 2.09 and 1.09 with resolution factor 3.4 and 0.4, respectively. The best separation of the enantiomers of the amine was achieved on amylose tris (3, 5\u2010dimethylphenylcarbamate) CSP with TFA additive in the mobile phase; in acidic conditions, instead, the best enantioseparation of the aminoalcohols was achieved on cellulose tris (3, 5\u2010dimethylphenilcarbamate). A long equilibration time of the CSP when switching from an undoped mobile phase to a doped one is required to obtain reproducible results. Chirality 19:647\u2013653, 2007 \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20438","type":"journal-article","created":{"date-parts":[[2007,6,14]],"date-time":"2007-06-14T04:17:22Z","timestamp":1181794642000},"page":"647-653","source":"Crossref","is-referenced-by-count":15,"title":["Direct high\u2010performance liquid chromatographic separation of the enantiomers of an aromatic amine and four aminoalcohols using polysaccharide chiral stationary phases and acidic additive"],"prefix":"10.1002","volume":"19","author":[{"given":"Salvatore","family":"Caccamese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Bianca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy T.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00532-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)80486-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00951-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00465-3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527611737.ch17"},{"key":"e_1_2_1_7_2","first-page":"83041","article-title":"Q6A Specifications: test procedure and acceptance criteria for new drug substances and new drug products: chemical substances","volume":"65","author":"Food and Drug Administration","year":"2000","journal-title":"Federal Register"},{"key":"e_1_2_1_8_2","unstructured":"European Agency for the Evaluation of Medicinal Products.Note for guidance on the investigation of bioavailability and bioequivalence. 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