{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:15:28Z","timestamp":1758636928116},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T00:00:00Z","timestamp":1196640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The resolution of five racemic \u03b1\u2010lactams (<jats:bold>1a\u2010d,g<\/jats:bold>) using HPLC is reported. Five different Pirkle\u2010type stationary phases were tested. The enantiomers of \u03b1\u2010lactams containing the trityl group (<jats:bold>1a\u2010d<\/jats:bold>) were separated (selectivity factors ranging from 1.08 to 1.20) using a mobile phase of hexane\/2\u2010propanol:98\/2 and a stationary phase consisting of the 3,5\u2010dinitroaniline derivative of (<jats:italic>S<\/jats:italic>)\u2010valine with a urea linkage. Among the dialkyl\u2010substituted \u03b1\u2010lactams (<jats:bold>1e\u2010g<\/jats:bold>), only 1,3\u2010di\u2010<jats:italic>tert<\/jats:italic>\u2010butylaziridinone (<jats:bold>1g<\/jats:bold>) could be resolved, but only partially (selectivity factor = 1.07), with a mobile phase of hexane\/1,2\u2010dichloroethane:95\/5 and the stationary phase consisting of the 3,5\u2010dinitrobenzoic acid derivative of (<jats:italic>R<\/jats:italic>)\u20101\u2010naphthylglycine. Chirality, 2008. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20499","type":"journal-article","created":{"date-parts":[[2007,12,3]],"date-time":"2007-12-03T14:16:24Z","timestamp":1196691384000},"page":"69-74","source":"Crossref","is-referenced-by-count":2,"title":["The resolution of five racemic \u03b1\u2010lactams by HPLC"],"prefix":"10.1002","volume":"20","author":[{"given":"Hui","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Cesare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.196800251"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198002761"},{"key":"e_1_2_1_4_2","first-page":"1","volume-title":"Houben\u2010Weyl, Methoden der Organischen Chemie, Vierte Auflage, Band E16b","author":"Backes J","year":"1991"},{"key":"e_1_2_1_5_2","first-page":"137","volume-title":"The amide linkage: selected structural aspects in chemistry, biochemistry, and material science","author":"Hoffman RV","year":"2000"},{"key":"e_1_2_1_6_2","series-title":"Science of synthesis, Houben\u2010Weyl methods of molecular transformations","first-page":"591","author":"Hoffman RV","year":"2005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3987\/COM-02-9585"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3987\/COM-02-9453"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo020246h"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/a800564h"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2003.11.067"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19911240427"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33652"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00911a026"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570380432"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01337a055"},{"key":"e_1_2_1_17_2","unstructured":"SuzukiY KirinoO HashimotoS MatsumotoK OshioH. 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