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For 2\u2010(<jats:italic>p<\/jats:italic>\u2010chlorophenoxy)acetic acid and 2\u2010<jats:italic>n<\/jats:italic>\u2010butyl\u20102\u2010(<jats:italic>p<\/jats:italic>\u2010chlorophenoxy)acetic acid ethyl esters, DMSO enhanced enzyme enantioselectivity more than IPA with an opposite enzymatic enantiopreference. The cosolvents moderately improved <jats:italic>Candida rugosa<\/jats:italic> lipase enantioselectivity for 2\u2010phenyl\u20102\u2010(<jats:italic>p<\/jats:italic>\u2010chlorophenoxy)acetic acid ethyl ester. 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