{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:33:04Z","timestamp":1768969984015,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T00:00:00Z","timestamp":1213920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This article reports a new chiral separation method\u2014biphasic recognition chiral extraction for the separation of mandelic acid enantiomers. Distribution behavior of mandelic acid enantiomers was studied in the extraction system with <jats:italic>O<\/jats:italic>,<jats:italic>O<\/jats:italic>\u2032\u2010di\u2010benzoyl\u2010(2S,3S)\u20104\u2010toluoyl\u2010tartaric acid (<jats:sc>D<\/jats:sc>\u2010(+)\u2010DTTA) in organic phase and \u03b2\u2010CD derivatives in aqueous phase, and the influence of the types and concentrations of extractants and pH on extraction efficiency was investigated. Hydroxypropyl\u2010\u03b2\u2010cyclodextrin (HP\u2010\u03b2\u2010CD), hydroxyethyl\u2010\u03b2\u2010cyclodextrin (HE\u2010\u03b2\u2010CD), and methyl\u2010\u03b2\u2010cyclodextrin (Me\u2010\u03b2\u2010CD) have stronger recognition abilities for <jats:italic>S<\/jats:italic>\u2010mandelic acid than those for <jats:italic>R<\/jats:italic>\u2010mandelic acid, among which HP\u2010\u03b2\u2010CD has the strongest ability. <jats:sc>D<\/jats:sc>\u2010(+)\u2010DTTA preferentially recognizes <jats:italic>R<\/jats:italic>\u2010mandelic acid. pH and the concentrations of extractants have great effects on chiral separation ability. A high enantioseparation efficiency with a maximum enantioselectivity of 1.527 is obtained at pH of 2.7 and the ratio of 2:1 of [<jats:sc>D<\/jats:sc>\u2010(+)\u2010DTTA] to [HP\u2010\u03b2\u2010CD]. The obtained results indicate that the biphasic recognition chiral extraction is of stronger chiral separation ability than the monophasic recognition chiral extraction. It may be very helpful to optimize the extraction systems and realize the large\u2010scale production of pure enantiomers. Chirality, 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20601","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T16:21:43Z","timestamp":1213978903000},"page":"390-395","source":"Crossref","is-referenced-by-count":49,"title":["Biphasic recognition chiral extraction: A novel method for separation of mandelic acid enantiomers"],"prefix":"10.1002","volume":"21","author":[{"given":"Kewen","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja045537h"},{"key":"e_1_2_1_3_2","first-page":"8622","article-title":"Highly enantioselective separation using a supported liquid membrane encapsulating surfactant\u2013enzyme complex","volume":"26","author":"Eijiro M","year":"2004","journal-title":"J Am Chem Soc"},{"key":"e_1_2_1_4_2","unstructured":"MillsJ SchmiegelKK ShawWN. Phenethanolamines compositions containing the same and method for effecting weight control. 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