{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T09:40:29Z","timestamp":1762249229350,"version":"3.35.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:00:00Z","timestamp":1219795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enantioselective pharmacokinetics of tenatoprazole were studied in Wistar rats after the administration of a single oral dose of<jats:italic>rac<\/jats:italic>\u2010tenatoprazole. Serial plasma samples were collected; and the pharmacokinetic behavior of each enantiomer was characterized using a sequential achiral and chiral liquid chromatographic method. Tenatoprazole was extracted from a small aliquot of plasma (100 \u03bcl) by one\u2010step extraction using hexane\u2010dichloromethane\u2010isopropanol (20:10:1, v\/v\/v) as extract solvent. Plasma drug concentration\u2013time data were analyzed for each enantiomer by using a noncompartmental method. The AUC<jats:sub>0\u2212\u221e<\/jats:sub>and<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>values of (+)\u2010tenatoprazole were significantly greater than those of (\u2212)\u2010tenatoprazole (<jats:italic>P<\/jats:italic>&lt; 0.001). The mean AUC<jats:sub>0\u2212\u221e<\/jats:sub>value of (+)\u2010tenatoprazole was 7.5 times greater than that of (\u2212)\u2010tenatoprazole after oral administration of<jats:italic>rac<\/jats:italic>\u2010tenatoprazole to rats at a dose of 5 mg\/kg. There are also significant differences in<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>and CL\/F (<jats:italic>P<\/jats:italic>&lt; 0.01and<jats:italic>P<\/jats:italic>&lt; 0.001, respectively) values between enantiomers. This study suggests that the pharmacokinetics of tenatoprazole are enantioselective in rats. Chirality, 2008. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20657","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T18:24:46Z","timestamp":1219861486000},"page":"613-618","source":"Crossref","is-referenced-by-count":6,"title":["Determination of tenatoprazole enantiomers and their enantioselective pharmacokinetics in rats"],"prefix":"10.1002","volume":"21","author":[{"given":"Jin","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Famei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,27]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2005.00517.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.11.030"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1211\/0022357991772510"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(02)00524-1"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90060-6"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200140060-00003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.724"},{"key":"e_1_2_1_9_2","first-page":"119","article-title":"Pharmacokinetic studies of (\u00b1)\u20105\u2010Methoxy\u20102\u2010[[(4\u2010methoxy\u20103,5\u2010dimethylpyrid\u20102\u2010yl) methyl]sulfinyl]\u20101H\u2010imidazo[4,5\u2010b]pyridine (TU\u2010199)","volume":"30","author":"Satio S","year":"1999","journal-title":"Iyakuhin Kenkyu"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.875"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1296698"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.584"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-005-6807-x"},{"key":"e_1_2_1_14_2","unstructured":"USFDA.2001:http:www.fda.gov\/guidance\/4252fnl.htm."},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0090-9556(24)15171-9","article-title":"Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes","volume":"28","author":"Abelo A","year":"2000","journal-title":"Durg Metab Dispos"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1998.tb03340.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.10.1227"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02566.x"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.20657","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.20657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T18:11:22Z","timestamp":1738347082000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.20657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,27]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/chir.20657"],"URL":"https:\/\/doi.org\/10.1002\/chir.20657","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"type":"print","value":"0899-0042"},{"type":"electronic","value":"1520-636X"}],"subject":[],"published":{"date-parts":[[2008,8,27]]}}}