{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:40:11Z","timestamp":1694583611580},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T00:00:00Z","timestamp":1272931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of phase appropriate technologies is critical for efficiently moving drug candidates forward in the early stages of drug discovery and development. Phase appropriate purification technology develops the analytical method and subsequently scales up the method and turns the sample around quickly (Kennedy et al., J Chromatogr A 2004; 1046:55). In this article, separation results and conditions from supercritical fluid chromatography (SFC), high\u2010performance liquid chromatography (HPLC), and steady\u2010state recycling (SSR) for the resolutions of three pharmaceutical intermediates in the early stage of the drug development are discussed. The first study used SFC and SSR to separate an impurity for a Good Manufacturing Practice (GMP) campaign. The analytical method development and scale\u2010up conditions are discussed. Productivity, solvent usage, and sample solubility under SFC and SSR conditions are also compared. The second study compared SFC to batch HPLC in separating a diastereomer. Due to higher separation efficiency, SFC was able to resolute multiple peaks. The third study involved the addition of dichloromethane as a co\u2010solvent in SFC purification\u2014improving sample selectivity and solubility. From the separation results of these purifications, SFC and SSR are clearly phase appropriate technologies in the early drug development stage. Chirality, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.20861","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T06:21:12Z","timestamp":1273040472000},"page":"922-928","source":"Crossref","is-referenced-by-count":6,"title":["Supercritical fluid chromatography and steady\u2010state recycling: Phase appropriate technologies for the resolutions of pharmaceutical intermediates in the early drug development stage"],"prefix":"10.1002","volume":"22","author":[{"given":"Tony Q.","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Orihuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay P.","family":"Preston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.01.015"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2003.08.015"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.10042"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1999)11:5\/6<440::AID-CHIR15>3.0.CO;2-K"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0021-9673(04)01071-4","article-title":"Comparison of separation efficiency of early phase active pharmaceutical intermediates by steady state recycle and batch chromatographic techniques","volume":"1046","author":"Kennedy JH","year":"2004","journal-title":"J Chromatogr A"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.03.124"},{"key":"e_1_2_6_8_2","first-page":"340","article-title":"The approaches to the difficult samples of singleton achiral purification for discovery research support in pharmaceutical industry","volume":"27","author":"Yan TQ","year":"2009","journal-title":"LC GC North America"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00952-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.000224"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20357"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00782-9"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.11.049"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)01047-9"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20451"},{"key":"e_1_2_6_16_2","first-page":"71","article-title":"Challenges and opportunities for the greening of separation science in the pharmaceutical industry","author":"Welch CJ","year":"2007","journal-title":"Drug Discov World"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20409"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.07.026"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/157341208784246288"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.08.034"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.20861","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.20861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:54:09Z","timestamp":1694523249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.20861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,4]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1002\/chir.20861"],"URL":"https:\/\/doi.org\/10.1002\/chir.20861","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,4]]}}}