{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:53:17Z","timestamp":1789451597892,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Liquid chromatographic separation of darunavir enantiomers on covalently bonded and physically adsorbed polysaccharide chiral stationary phases was studied at different temperatures. The separations were accomplished under normal\u2010phase conditions by using different combinations of hexane, organic modifiers (2\u2010propanol, 1\u2010propanol and ethanol), and diethylamine as mobile phase solvents. The effect of organic modifiers and the column temperature on retention, separation, and resolution was investigated. The observed differences were explained in terms of the coated and immobilized nature of the two columns. Van't Hoff plots (ln <jats:italic>k<\/jats:italic>\u2032 vs. 1\/T, ln \u03b1 vs. 1\/T) and apparent thermodynamic parameters were derived to understand the effect of temperature on separation. <jats:italic>Chirality 24:652\u2013660, 2012<\/jats:italic>. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/chir.22060","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T05:44:26Z","timestamp":1337665466000},"page":"652-660","source":"Crossref","is-referenced-by-count":18,"title":["Liquid Chromatographic Separation of Darunavir Enantiomers on Coated and Immobilized Amylose Tris(3, 5\u2010Dimethylphenylcarbamate) Chiral Stationary Phases"],"prefix":"10.1002","volume":"24","author":[{"given":"Ramisetti Nageswara","family":"Rao","sequence":"first","affiliation":[{"name":"Analytical Chemistry Division, D215, Discovery Laboratory Indian Institute of Chemical Technology  Tarnaka Hyderabad 500607 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandukuri Nagesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Division, D215, Discovery Laboratory Indian Institute of Chemical Technology  Tarnaka Hyderabad 500607 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Challa Gangu","family":"Naidu","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Division, D215, Discovery Laboratory Indian Institute of Chemical Technology  Tarnaka Hyderabad 500607 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