{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:03:01Z","timestamp":1778400181138,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>C75 is a synthetic compound described as having antitumoral properties. It produces hypophagia and weight loss in rodents, limiting its use in cancer therapy but identifying it as a potential anti\u2010obesity drug. C75 is a fatty acid synthase (FAS) inhibitor and, through its coenzyme A (CoA) derivative, it acts as a carnitine palmitoyltransferase (CPT) 1 inhibitor. Racemic mixtures of C75 have been used in all the previous studies; however, the potential different biological activities of C75 enantiomers have not been examined yet. To address this question we synthesized the two C75 enantiomers separately. Our results showed that (\u2212)\u2010C75 inhibits FAS activity in vitro and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)\u2010C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity. <jats:italic>Chirality 25:281\u2013287, 2013<\/jats:italic>. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/chir.22139","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T08:59:16Z","timestamp":1366966756000},"page":"281-287","source":"Crossref","is-referenced-by-count":34,"title":["Differential Pharmacologic Properties of the Two C75 Enantiomers: (+)\u2010C75 Is a Strong Anorectic Drug; (\u2212)\u2010C75 Has Antitumor Activity"],"prefix":"10.1002","volume":"25","author":[{"given":"Kamil","family":"Makowski","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Facultat de Farm\u00e0cia Universitat de Barcelona, E\u201008028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III  Spain"},{"name":"Department of Organic Chemistry, Facultat de Qu\u00edmica Universitat de Barcelona, E\u201008028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Mera","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Facultat de Farm\u00e0cia Universitat de Barcelona, E\u201008028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Paredes","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Facultat de Qu\u00edmica Universitat de Barcelona, E\u201008028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Herrero","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Facultat de Farm\u00e0cia Universitat de Barcelona, E\u201008028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Ariza","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Facultat de Qu\u00edmica Universitat de Barcelona, E\u201008028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermina","family":"Asins","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Facultat de Farm\u00e0cia 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