{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:58:00Z","timestamp":1778907480063,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Baden-W\u00fcrttemberg Stiftung (Eliteprogramme for Postdocs)","award":["1.16101.09"],"award-info":[{"award-number":["1.16101.09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Changes in vibrational circular dichroism (VCD) were recorded on\u2010line during a chemical reaction. The chiral complex nickel\u2010(\u2013)\u2010sparteine chloride was hydrolyzed to free (\u2013)\u2010sparteine base in a biphasic system of sodium hydroxide solution and chloroform (CHCl<jats:sub>3<\/jats:sub>). Infrared (IR) and VCD spectra were iteratively recorded after pumping a sample from the CHCl<jats:sub>3<\/jats:sub> phase through a lab\u2010built VCD spectrometer equipped with a tunable mid\u2010IR quantum cascade laser light source, which allows for VCD measurements even in the presence of strongly absorbing backgrounds. Time\u2010dependent VCD spectra were analyzed by singular value decomposition and global exponential fitting. Spectral features corresponding to the complex and free (\u2013)\u2010sparteine could be clearly identified in the fitted amplitude spectrum, which was associated with an exponential decay with an apparent time constant of 127 min (<jats:italic>t<\/jats:italic><jats:sub>\u00bd<\/jats:sub> = 88 min). <jats:italic>Chirality 26:490\u2013496, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/chir.22307","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T17:36:39Z","timestamp":1394645799000},"page":"490-496","source":"Crossref","is-referenced-by-count":21,"title":["Reaction Monitoring Using Mid\u2010Infrared Laser\u2010Based Vibrational Circular Dichroism"],"prefix":"10.1002","volume":"26","author":[{"given":"Anja","family":"R\u00fcther","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences Albert\u2010Ludwigs\u2010Universit\u00e4t Freiburg  Freiburg 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