{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:49:33Z","timestamp":1760888973843},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T00:00:00Z","timestamp":1413331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grand Project of Science Research for the 11th Five-year Plan Funded by Ministry of Science & Technology of China","award":["2009ZX09103-146"],"award-info":[{"award-number":["2009ZX09103-146"]}]},{"name":"research and development project in Hubei Province","award":["2008BCB103"],"award-info":[{"award-number":["2008BCB103"]}]},{"name":"the Important National Science & Technology Specific Projects in Wuhan City","award":["2009ZX09301-014"],"award-info":[{"award-number":["2009ZX09301-014"]}]},{"name":"the Wuhan New Drug Development Program","award":["20066002103"],"award-info":[{"award-number":["20066002103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enantioselective pharmacokinetics of TJ0711 hydrochloride were studied in rats given different doses of rac\u2010TJ0711 hydrochloride via intravenous and oral routes. R\u2010 and S\u2010TJ0711 hydrochloride were both rapidly absorbed, and the average AUC<jats:sub>0\u2010\u221e<\/jats:sub> of R\u2010TJ0711 hydrochloride was greater than that of S\u2010TJ0711 hydrochloride after intragastric administration, with an R\/S AUC ratio 1.11 and 1.35 for 30 and 50 mg\/kg dose group, respectively. In contrast, the average AUC<jats:sub>0\u2010\u221e<\/jats:sub> of R\u2010TJ0711 hydrochloride was smaller than that of S\u2010TJ0711 hydrochloride after intravenous injection, with an R\/S AUC ratio 0.57 and 0.73 for 10 and 20 mg\/kg dose group, respectively. R\u2010TJ0711 hydrochloride plasma half\u2010lives were shorter than those of S\u2010TJ0711 hydrochloride for all groups. AUC<jats:sub>0\u20104h<\/jats:sub> and C<jats:sub>max<\/jats:sub> between the two enantiomers were significantly different after oral administration of 50 mg\/kg dose of the racemate, while no significant differences between the two enantiomers were found for all the pharmacokinetic parameters of the 30 mg\/kg dose group. Significant differences between the two enantiomers were detected for nearly all the pharmacokinetic parameters after intravenous administration, except for the V<jats:sub>Z<\/jats:sub> of 20 mg\/kg dose group. This study suggests that dose and route of administration will influence the enantioselectivity in the pharmacokinetics of TJ0711 hydrochloride in rats. <jats:italic>Chirality 27:53\u201357, 2015<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/chir.22387","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T04:55:51Z","timestamp":1413348951000},"page":"53-57","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Dose and Route of Administration on the Enantioselective Pharmacokinetics of TJ0711 Hydrochloride in Rats"],"prefix":"10.1002","volume":"27","author":[{"given":"Shuping","family":"Sun","sequence":"first","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"},{"name":"Department of Biotechnology and Pharmaceutical Engineering Wuhan Polytechnic University  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoze","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqin","family":"Si","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(01)00076-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(01)00318-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.04.027"},{"key":"e_1_2_6_5_1","unstructured":"ChenBY LiG QiuJ SiLQ SunSP.C.N. 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