{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:12:41Z","timestamp":1783109561781,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Endeavour Program, Australian Gov.","award":["ERF_PDR_3853_2014"],"award-info":[{"award-number":["ERF_PDR_3853_2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A comparative enantioselective analysis using immobilized amylose tris\u2010(3\u2010chlorophenylcarbamate) as chiral stationary phase in conventional high\u2010performance liquid chromatography (HPLC) with Chiralpak ID (4.6\u2009mm ID\u2009\u00d7\u2009250\u2009mm, 5\u2009\u00b5m silica gel) and micro\u2010HPLC with Chiralpak ID\u20103 (0.30\u2009mm ID\u2009\u00d7\u2009150\u2009mm, 3\u2009\u00b5m silica gel) was conducted. Pharmaceutical racemates of 12 pharmacological classes, namely, \u03b1\u2010 and \u03b2\u2010blockers, anti\u2010inflammatory drugs, antifungal drugs, dopamine antagonists, norepinephrine\u2010dopamine reuptake inhibitors, catecholamines, sedative hypnotics, diuretics, antihistaminics, anticancer drugs, and antiarrhythmic drugs were screened under normal phase conditions. The effect of an organic modifier on the analyte retentions and enantiomer recognition was investigated. Baseline separation was achieved for 1\u2010acenaphthenol, carprofen, celiprolol, cizolirtine carbinol, miconazole, tebuconazole, 4\u2010hydroxy\u20103\u2010methoxymandelic acid, 1\u2010indanol, 1\u2010(2\u2010chlorophenyl)ethanol, 1\u2010phenyl\u20102\u2010propanol, flavanone, 6\u2010hydroxyflavanone, 4\u2010bromogluthethimide, and pentobarbital on the 4.6\u2009mm ID packed with a 5\u2009\u00b5m silica column using conventional HPLC. Nonetheless, baseline separation was achieved for aminoglutethimide, naftopidil, and thalidomide on the 0.3\u2009mm ID packed with a 3\u2009\u00b5m silica capillary column. <jats:italic>Chirality 26:677\u2013682, 2014<\/jats:italic>. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/chir.22390","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T10:44:27Z","timestamp":1412160267000},"page":"677-682","source":"Crossref","is-referenced-by-count":21,"title":["Conventional Chiralpak ID vs. Capillary Chiralpak ID\u20103 Amylose Tris\u2010(3\u2010Chlorophenylcarbamate)\u2010Based Chiral Stationary Phase Columns for the Enantioselective HPLC Separation of Pharmaceutical Racemates"],"prefix":"10.1002","volume":"26","author":[{"given":"Marwa","family":"Ahmed","sequence":"first","affiliation":[{"name":"Chirality Program, Biomedical Science University of Canberra  Australian Capital Territory (ACT) Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Gwairgi","sequence":"additional","affiliation":[{"name":"Chirality Program, Biomedical Science University of Canberra  Australian Capital Territory (ACT) Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Chirality Program, Biomedical Science University of Canberra  Australian Capital Territory (ACT) Canberra Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990198"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.07.070"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00951-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900805"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.05.043"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.10.022"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200401819"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.12.051"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200500388"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2002.23.7.1014"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2012.05.055"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200443"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.09.071"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.10.080"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.10.033"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bms047"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1081\/JLC-120034088"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800667"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.05.029"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200202)23:3<486::AID-ELPS486>3.0.CO;2-L"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.09.024"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.07.099"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00156-4"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20010101)24:1<27::AID-JSSC27>3.0.CO;2-G"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.22390","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.22390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T10:53:47Z","timestamp":1694602427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.22390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/chir.22390"],"URL":"https:\/\/doi.org\/10.1002\/chir.22390","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}