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Plasma samples were prepared by liquid\u2013liquid extraction using methyl tert\u2010butyl ether as the extraction solvent. Direct resolution of the R\u2010 and S\u2010isomers was performed on a CHIRALCEL OJ\u2010RH column (4.6\u00a0\u00d7\u00a0150\u00a0mm, 5\u00a0\u03bcm) using acetonitrile \/ 0.1% formic acid \/ 1\u00a0mM ammonium acetate as the mobile phase. Detection was operated by electron spray ionization in the selected ion monitoring and positive ion mode. The target ions at <jats:italic>m\/z<\/jats:italic> 262.1 and m\/z 260.1 were selected for the quantification of the enantiomers and IS, respectively. The linear range was 0.5\u2013500\u00a0ng\/mL. The precisions (coefficient of variation, CV%) and recoveries were 1.43\u20138.68 and 94.24\u2013106.76%, respectively. The lowest quantitation limit for both enantiomers is 0.5\u00a0ng\/mL, which is sensitive enough to be applied to sample analysis in other related studies.<\/jats:p>","DOI":"10.1002\/chir.22654","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T11:03:46Z","timestamp":1477652626000},"page":"737-743","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of flumequine enantiomers in rat plasma by UFLC\u2010ESI\u2010MS\/MS"],"prefix":"10.1002","volume":"28","author":[{"given":"Zhao\u2013Hong","family":"Hu","sequence":"first","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan Peoples Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang\u2013Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan Peoples Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huo\u2013Xi","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan Peoples Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2013Kun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan Peoples Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2013Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan Peoples Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/69.2.317"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2015.05.003"},{"key":"e_1_2_6_4_1","unstructured":"(EMEA) ECsicwtEMA.Notice to applicants and Guideline Veterinary medicinal products. 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