{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:47Z","timestamp":1786977347959,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Innovation Drugs in Liaoning Province","award":["No. 2009ZX09301-012"],"award-info":[{"award-number":["No. 2009ZX09301-012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>\n \n The purpose of this study was to compare intestinal permeability between enantiomers of 2\u2010(2\u2010hydroxypropanamido) benzoic acid ((\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA), a marine\u2010derived antiinflammatory drug, using an in situ single\u2010pass intestinal perfusion (SPIP) model in rats. Concentrations, isolated regions of small intestine, and\n p<\/jats:italic>\n \u2010glycoprotein (P\u2010gp) inhibitor were performed to investigate their influences on the intestinal absorption of (\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA. In addition, a molecular docking method was performed to illustrate our prediction. The absorption rate coefficients (\n K<\/jats:italic>\n \n a<\/jats:italic>\n <\/jats:sub>\n ) and permeability values (\n P<\/jats:italic>\n \n eff<\/jats:italic>\n <\/jats:sub>\n ) of (\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA were calculated. The permeability of (\n S<\/jats:italic>\n )\u2010HPABA was significantly (\n P\u00a0<<\/jats:italic>\n \u00a00.01) higher than that of (\n R<\/jats:italic>\n )\u2010HPABA in jejunum, and ileum permeability of (\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA appeared best in ileum; the investigated concentrations ranged from 20 to 80\u00a0\u03bcg\/mL,\n K<\/jats:italic>\n \n a<\/jats:italic>\n <\/jats:sub>\n and\n P<\/jats:italic>\n \n eff<\/jats:italic>\n <\/jats:sub>\n values of (\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA increased linearly; in the presence of P\u2010gp inhibitor (verapamil),\n P<\/jats:italic>\n \n eff<\/jats:italic>\n <\/jats:sub>\n values of two enantiomers were increased significantly; and the effect of P\u2010gp on absorption of (\n R<\/jats:italic>\n )\u2010HPABA is stronger than that of (\n S<\/jats:italic>\n )\u2010HPABA in ileum segment. Based on these results, carrier\u2010mediated transport or passive transport combined with carrier\u2010mediated transport seems to be the mechanism for intestinal absorption of (\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA, and (\n R<\/jats:italic>\n )\n \u2010\/<\/jats:italic>\n (\n S<\/jats:italic>\n )\n \u2010<\/jats:italic>\n HPABA may be recognized as the P\u2010gp substrate. In addition, the intestinal permeability of (\n S<\/jats:italic>\n )\u2010HPABA is higher than that of (\n R<\/jats:italic>\n )\u2010HPABA.\n <\/jats:p>","DOI":"10.1002\/chir.22662","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T10:10:44Z","timestamp":1482142244000},"page":"26-32","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of intestinal permeability and\n p<\/i>\n \u2010glycoprotein effects on the intestinal absorption of enantiomers of 2\u2010(2\u2010hydroxypropanamido) benzoic acid in rats"],"prefix":"10.1002","volume":"29","author":[{"given":"Qili","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danlin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunli","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2234"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.12.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.08.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.03.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.59566\/IJBS.2006.2085","article-title":"Chiral drugs. 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