{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:22:18Z","timestamp":1788355338893,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["No. 2015C37034"],"award-info":[{"award-number":["No. 2015C37034"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six novel regioselectively substituted amylose derivatives with a benzoate at 2\u2010position and two different phenylcarbamates at 3\u2010 and 6\u2010positions were synthesized and their structures were characterized by <jats:sup>1<\/jats:sup>H nuclear magnetic resonance (NMR) spectroscopy. Their enantioseparation abilities were then examined as chiral stationary phases (CSPs) for high\u2010performance liquid chromatography (HPLC) after they were coated on 3\u2010aminopropyl silica gels. Investigations indicated that the substituents at the 3\u2010 and 6\u2010positions played an important role in chiral recognition of these amylose 2\u2010benzoate serial derivatives. The derivatives demonstrated characteristic enantioseparation and some racemates were better resolved on these derivatives than on Chiralpak AD, which is one of the most efficient CSPs, utilizing coated amylose tris(3,5\u2010dimethylphenylcarbamate) as the chiral selector. Among the derivatives prepared, amylose 2\u2010benzoate\u20103\u2010(phenylcarbamate\/4\u2010methylphenylcarbamate)\u20106\u2010(3,5\u2010dimethylphenylcarbamate) exhibited chiral recognition abilities comparable to that of Chiralpak AD and may be useful CSPs in the future. The effect of mobile phase on chiral recognition was also studied. In general, with the decreased concentration of 2\u2010propanol, better resolutions were obtained with longer retention times. Moreover, when ethanol was used instead of 2\u2010propanol, poorer resolutions were often achieved. However, in some cases, improved enantioselectivity was achieved with ethanol rather than 2\u2010propanol as the mobile phase modifier.<\/jats:p>","DOI":"10.1002\/chir.22720","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T08:16:36Z","timestamp":1498032996000},"page":"512-521","source":"Crossref","is-referenced-by-count":10,"title":["Preparation and evaluation of regioselectively substituted amylose derivatives for chiral separations"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-8912","authenticated-orcid":false,"given":"Shouwan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Pharmaceutical and Chemical Engineering Taizhou University  Taizhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolei","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University  Hangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baishen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Pharmaceutical and Chemical Engineering Taizhou University  Taizhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Pharmaceutical and Chemical Engineering Taizhou University  Taizhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Pharmaceutical and Chemical Engineering Taizhou University  Taizhou People's Republic of 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