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Important factors affecting the extraction efficiency were investigated, including the type of chiral extractant, pH value of aqueous phase, initial concentration of chiral extractant in organic phase, initial concentration of 4\u2010ClMA in aqueous phase, and resolution temperature. It was observed that the concentration of (R)\u20104\u2010ClMA was much higher than that of (S)\u20104\u2010ClMA in organic phase due to a higher stability of the complex formed between (R)\u20104\u2010ClMA and 2\u2010Cl\u2010Z\u2010AA. A separation factor (\u03b1) of 3.05 was obtained at 0.02 mol\/L 2\u2010Cl\u2010Z\u2010Valine dissolved in dichloromethane, pH of 2.0, concentration of 4\u2010ClMA of 0.11 mmol\/Land T of 296.7K.<\/jats:p>","DOI":"10.1002\/chir.22738","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:26:42Z","timestamp":1503476802000},"page":"708-715","source":"Crossref","is-referenced-by-count":7,"title":["Enantioselective resolution of 4\u2010chloromandelic acid by liquid\u2013liquid extraction using 2\u2010chloro\u2010N\u2010carbobenzyloxy\u2010L\u2010amino acid"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1761-6130","authenticated-orcid":false,"given":"Ruichen","family":"Lu","sequence":"first","affiliation":[{"name":"School of Chemical Engineering East China University of Science and Technology  Shanghai 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